naringin [Ligand Id: 4738] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL451532 (Naringin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Inhibition of aromatase | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Nat Prod (2008) 71: 1082-1084 [PMID:18462007] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of Homo sapiens (human) recombinant GSK3beta after 30 min by Kinase-Glo assay | B | 4 | pIC50 | 100000 | nM | IC50 | Med Chem Res (2013) 22: 3061-3075 |
| Kir3.2/Kir3.1/Kir3.1/Kir3.2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038489] [GtoPdb: 435, 434] [UniProtKB: P48051, P48549] | ||||||||
| ChEMBL | Activation of recombinant human GIRK1/2 expressed in Xenopus oocytes by two-electrode voltage clamp method | B | 4 | pEC50 | >100000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 5195-5198 [PMID:23916258] |
| Kir3.4/Kir3.1/Kir3.1/Kir3.4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038488] [GtoPdb: 437, 434] [UniProtKB: P48544, P48549] | ||||||||
| ChEMBL | Activation of recombinant human GIRK1/4 expressed in Xenopus oocytes by two-electrode voltage clamp method | B | 4 | pEC50 | >100000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 5195-5198 [PMID:23916258] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate pretreated for 10 mins followed by substrate addition measured after 20 mins by spectrophotometric method | B | 4.04 | pIC50 | 91800 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2274-2280 [PMID:28454670] |
| ChEMBL | Inhibition of human recombinant PTP1B | B | 4.22 | pIC50 | >60000 | nM | IC50 | J Nat Prod (2006) 69: 1572-1576 [PMID:17125223] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
