naringin [Ligand Id: 4738] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL451532 (Naringin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Inhibition of aromatase | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Nat Prod (2008) 71: 1082-1084 [PMID:18462007] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of Homo sapiens (human) recombinant GSK3beta after 30 min by Kinase-Glo assay | B | 4 | pIC50 | 100000 | nM | IC50 | Med Chem Res (2013) 22: 3061-3075 |
| Kir3.2/Kir3.1/Kir3.1/Kir3.2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038489] [GtoPdb: 435, 434] [UniProtKB: P48051, P48549] | ||||||||
| ChEMBL | Activation of recombinant human GIRK1/2 expressed in Xenopus oocytes by two-electrode voltage clamp method | B | 4 | pEC50 | >100000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 5195-5198 [PMID:23916258] |
| Kir3.4/Kir3.1/Kir3.1/Kir3.4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038488] [GtoPdb: 437, 434] [UniProtKB: P48544, P48549] | ||||||||
| ChEMBL | Activation of recombinant human GIRK1/4 expressed in Xenopus oocytes by two-electrode voltage clamp method | B | 4 | pEC50 | >100000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 5195-5198 [PMID:23916258] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate pretreated for 10 mins followed by substrate addition measured after 20 mins by spectrophotometric method | B | 4.04 | pIC50 | 91800 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2274-2280 [PMID:28454670] |
| ChEMBL | Inhibition of human recombinant PTP1B | B | 4.22 | pIC50 | >60000 | nM | IC50 | J Nat Prod (2006) 69: 1572-1576 [PMID:17125223] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
