dextrorphan [Ligand Id: 9052] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1254766 (Dextrorphan)
  • Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
  • This target only has 1 pki data point
  • 4.7
1 CHEMBL1254766_lig_chart_1 Acetylcholinesterase Electrophorus electricus
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2 CHEMBL1254766_lig_chart_2 Glutamate [NMDA] receptor Human
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  • GluN1/GluN2A/Glutamate NMDA receptor; GRIN1/GRIN2A in Human [ChEMBL: CHEMBL1907604] [GtoPdb: 455456] [UniProtKB: Q05586Q12879]
  • This target only has 0 pki data point
  • 0
3 CHEMBL1254766_lig_chart_3 Glutamate NMDA receptor; GRIN1/GRIN2A Human
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  • GluN1/GluN2B/Glutamate NMDA receptor; GRIN1/GRIN2B in Human [ChEMBL: CHEMBL1907603] [GtoPdb: 455457] [UniProtKB: Q05586Q13224]
  • This target only has 0 pki data point
  • 0
4 CHEMBL1254766_lig_chart_4 Glutamate NMDA receptor; GRIN1/GRIN2B Human
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  • Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
  • This target only has 0 pki data point
  • 0
5 CHEMBL1254766_lig_chart_5 Solute carrier family 22 member 1 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL Inhibition of electric eel AChE by Ellman's method B 4.7 pKi 20000 nM Ki Bioorg. Med. Chem. (2010) 18: 5071-5080 [PMID:20580236]
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459461455456457458460] [UniProtKB: O15399O60391Q05586Q12879Q13224Q14957Q8TCU5]
ChEMBL The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. B 6.66 pKi 220 nM Ki J. Med. Chem. (1998) 41: 393-400 [PMID:9464369]
GtoPdb Measured vs. exogenously expressed zeta1/epsilon3 (GRIN1/GRIN2C) subunits, at pH 6.9 - 6.94 pIC50 114 nM IC50 J Physiol (Lond.) (2007) 581: 107-28 [PMID:17303642]
GluN1/GluN2A/Glutamate NMDA receptor; GRIN1/GRIN2A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907604] [GtoPdb: 455456] [UniProtKB: Q05586Q12879]
ChEMBL Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at pH 7.6 at -40mV holding potential by two-electrode voltage-clamp electrophysiology B 5.89 pIC50 1300 nM IC50 Bioorg. Med. Chem. (2014) 22: 1983-1992 [PMID:24630693]
GluN1/GluN2B/Glutamate NMDA receptor; GRIN1/GRIN2B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907603] [GtoPdb: 455457] [UniProtKB: Q05586Q13224]
ChEMBL Antagonist activity at NR1/2B receptor expressed in xenopus laevis at pH 6.9 by two electrode voltage clamp method F 6.61 pIC50 246 nM IC50 J. Med. Chem. (2008) 51: 3765-3776 [PMID:18540667]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis B 5.22 pIC50 6000 nM IC50 J Med Chem (2019) 62: 9890-9905 [PMID:31597043]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]