ChEMBL ligand: CHEMBL46909 (Trans-2,4,3',5'-Tetramethoxystilbene)
CYP1A1/Cytochrome P450 1A1 in Human [ChEMBL: CHEMBL2231] [GtoPdb: 1318] [UniProtKB: P04798] There should be some charts here, you may need to enable JavaScript!
CYP1A2/Cytochrome P450 1A2 in Human [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] There should be some charts here, you may need to enable JavaScript!
CYP1B1/Cytochrome P450 1B1 in Human [ChEMBL: CHEMBL4878] [GtoPdb: 1320] [UniProtKB: Q16678] There should be some charts here, you may need to enable JavaScript!
tyrosinase/Tyrosinase in Human [ChEMBL: CHEMBL1973] [GtoPdb: 2643] [UniProtKB: P14679] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP1A1/Cytochrome P450 1A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2231] [GtoPdb: 1318] [UniProtKB: P04798]
ChEMBL	Inhibition of recombinant human CYP1A1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyresorufin O-de-ethylation preincubated for 3 mins followed by NADPH addition and measured after 10 mins by fluorometric method	B	6.52	pIC50	300	nM	IC50	ACS Med Chem Lett (2018) 9: 1247-1252 [PMID:30613334]
CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177]
ChEMBL	Inhibition of recombinant human CYP1A2 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyresorufin O-de-ethylation preincubated for 3 mins followed by NADPH addition and measured after 10 mins by fluorometric method	B	5.51	pIC50	3100	nM	IC50	ACS Med Chem Lett (2018) 9: 1247-1252 [PMID:30613334]
CYP1B1/Cytochrome P450 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4878] [GtoPdb: 1320] [UniProtKB: Q16678]
ChEMBL	Inhibition of human CYP1B1 using ethoxyresorufin as substrate preincubated for 3 mins followed by NADPH addition measured after 10 mins by EROD assay	B	8.52	pKi	3	nM	Ki	Eur J Med Chem (2019) 163: 28-36 [PMID:30503941]
ChEMBL	Inhibition of human CYP1B1 expressed in Escherichia coli assessed as changes in ethoxyresorufin O-deethylation activity after 3 mins by spectrofluorometer analysis	B	6.52	pIC50	300	nM	IC50	Medchemcomm (2011) 2: 402-405
GtoPdb	-	-	8.22	pIC50	6	nM	IC50	J Med Chem (2002) 45: 160-4 [PMID:11754588]
ChEMBL	Inhibition of recombinant human CYP1B1 expressed in Escherichia coli DH5aplha cells assessed as O-deethylation of ethoxyresorufin in presence of NADPH measured after 2 mins by spectrofluorometric method	B	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3243-3247 [PMID:27265259]
ChEMBL	Inhibition of recombinant human CYP1B1 expressed in Escherichia coli DH5alpha using ethoxyresorufin as substrate preincubated for 3 mins followed by NADPH addition measured after 10 mins by spectrofluorometric assay	B	8.22	pIC50	6	nM	IC50	Eur J Med Chem (2017) 135: 296-306 [PMID:28458135]
ChEMBL	Inhibition of recombinant human CYP1B1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyresorufin O-de-ethylation preincubated for 3 mins followed by NADPH addition and measured after 10 mins by fluorometric method	B	8.22	pIC50	6	nM	IC50	ACS Med Chem Lett (2018) 9: 1247-1252 [PMID:30613334]
ChEMBL	Inhibition of CYP1B1 in human liver microsomes by 7-ethoxyresorufin-O-deethylation-based spectrofluorimetry	B	8.7	pIC50	2	nM	IC50	Medchemcomm (2014) 5: 496-501
tyrosinase/Tyrosinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1973] [GtoPdb: 2643] [UniProtKB: P14679]
ChEMBL	Inhibition of tyrosinase	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5650-5653 [PMID:16919455]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]