ChEMBL ligand: CHEMBL179691 (NBI-42902)

Gonadotropin-releasing hormone receptor in Rhesus macaque [ChEMBL: CHEMBL5647] [UniProtKB: Q8SPZ1] GnRH1 receptor/Gonadotropin-releasing hormone receptor in Human [ChEMBL: CHEMBL1855] [GtoPdb: 256] [UniProtKB: P30968] GnRH1 receptor/Gonadotropin-releasing hormone receptor in Rat [ChEMBL: CHEMBL3066] [GtoPdb: 256] [UniProtKB: P30969] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Gonadotropin-releasing hormone receptor in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5647] [UniProtKB: Q8SPZ1]
ChEMBL	Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from monkey GnRH receptor expressed in CHO cells by liquid scintillation counting	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2008) 51: 7478-7485 [PMID:19006286]
ChEMBL	Binding affinity at monkey GnRH receptor	B	8.46	pKi	3.5	nM	Ki	J Med Chem (2008) 51: 3331-3348 [PMID:18419112]
GnRH1 receptor/Gonadotropin-releasing hormone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1855] [GtoPdb: 256] [UniProtKB: P30968]
GtoPdb	-	-	9.7	pKd	-	-	-	Biochem Pharmacol (2006) 72: 838-49 [PMID:16930559]
ChEMBL	Binding affinity for Monkey gonadotropin-releasing hormone receptor	B	8.46	pKi	3.5	nM	Ki	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Binding affinity for Human gonadotropin-releasing hormone receptor	B	9.25	pKi	0.56	nM	Ki	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Binding affinity for Human gonadotropin-releasing hormone receptor	B	9.25	pKi	0.56	nM	Ki	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Binding affinity to human GnRHR	B	9.25	pKi	0.56	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3344-3349 [PMID:18442905]
ChEMBL	Binding affinity at human GnRH receptor	B	9.25	pKi	0.56	nM	Ki	J Med Chem (2008) 51: 3331-3348 [PMID:18419112]
ChEMBL	Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting	B	9.25	pKi	0.56	nM	Ki	J Med Chem (2008) 51: 7478-7485 [PMID:19006286]
ChEMBL	Binding affinity towards human gonadotropin-releasing hormone receptor (GNRHR) using GnRH peptide as radioligand	B	9.25	pKi	0.56	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2519-2522 [PMID:15863308]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S118N	B	5.28	pIC50	5200	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24A	B	5.3	pIC50	5030	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24T	B	5.3	pIC50	5000	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24I	B	5.38	pIC50	4200	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K121A	B	6.01	pIC50	980	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290Q	B	6.58	pIC50	262	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290L	B	6.74	pIC50	182	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284L	B	6.91	pIC50	123	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Antagonist activity against human GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 20 nM GnRH-induced NFAT activation pre-incubated for 1 hr before GnRH stimulation and measured after 6 hrs by luciferase reporter gene assay	B	7.06	pIC50	87	nM	IC50	J Med Chem (2016) 59: 9150-9172 [PMID:27608177]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300K	B	7.1	pIC50	80	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q208D	B	7.37	pIC50	42.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300A	B	7.62	pIC50	24.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F313L	B	7.82	pIC50	15.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y283F	B	7.86	pIC50	13.9	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306K	B	7.94	pIC50	11.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q208E	B	8.04	pIC50	9.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300V	B	8.05	pIC50	8.9	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203P	B	8.1	pIC50	8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N27E	B	8.12	pIC50	7.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F309Q	B	8.18	pIC50	6.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293K	B	8.24	pIC50	5.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR W280F	B	8.26	pIC50	5.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293N	B	8.43	pIC50	3.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293A	B	8.47	pIC50	3.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290F	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR W291F	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S124A	B	8.51	pIC50	3.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Inhibition of Human gonadotropin-releasing hormone receptor stimulated calcium flux	B	8.52	pIC50	3	nM	IC50	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293E	B	8.52	pIC50	3	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Antagonist activity at human GnRH receptor expressed in RBL1 cells assessed as inhibition of GnRH-stimulated inositol phosphate production	F	8.55	pIC50	2.8	nM	IC50	J Med Chem (2008) 51: 7478-7485 [PMID:19006286]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F309L	B	8.55	pIC50	2.8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K115Q	B	8.57	pIC50	2.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306E	B	8.57	pIC50	2.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302N	B	8.59	pIC50	2.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N27A	B	8.6	pIC50	2.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N315A	B	8.62	pIC50	2.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284F	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112F	B	8.74	pIC50	1.8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302A	B	8.74	pIC50	1.8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302Q	B	8.77	pIC50	1.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S186K	B	8.77	pIC50	1.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295Q	B	8.8	pIC50	1.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305K	B	8.8	pIC50	1.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR T190K	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F272L	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112A	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S168I	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N315D	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295K	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203E	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305D	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111Q	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203Q	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306A	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189E	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S118A	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L117A	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189P	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR T51A	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR A50T	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112K	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S186D	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295A	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S168A	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K191E	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189K	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189A	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203K	B	9	pIC50	1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305A	B	9	pIC50	1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from human wild type GnRHR	B	9.05	pIC50	0.9	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111A	B	9.1	pIC50	0.8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111K	B	9.15	pIC50	0.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H182E	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cells after 1 hr by microbeta scintillation counting method	B	9.23	pIC50	0.59	nM	IC50	Eur J Med Chem (2018) 145: 413-424 [PMID:29335207]
ChEMBL	Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cell membranes incubated for 1 hr by competitive binding assay	B	9.23	pIC50	0.59	nM	IC50	J Med Chem (2016) 59: 9150-9172 [PMID:27608177]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H182A	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
GnRH1 receptor/Gonadotropin-releasing hormone receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3066] [GtoPdb: 256] [UniProtKB: P30969]
ChEMBL	Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from rat GnRH receptor expressed in CHO cells by liquid scintillation counting	B	5.21	pKi	6100	nM	Ki	J Med Chem (2008) 51: 7478-7485 [PMID:19006286]
ChEMBL	Binding affinity for rat gonadotropin-releasing hormone receptor	B	5.52	pKi	3000	nM	Ki	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Binding affinity at rat GnRH receptor	B	5.52	pKi	3000	nM	Ki	J Med Chem (2008) 51: 3331-3348 [PMID:18419112]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]