WLL-vs [Ligand Id: 11321] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4456306 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 measured after 72 hrs by SYBR green dye based fluorescence assay | F | 7.04 | pEC50 | 91.6 | nM | EC50 | J Med Chem (2019) 62: 6137-6145 [PMID:31177777] |
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta5 proteasome A49S mutant measured after 72 hrs by SYBR green dye based fluorescence assay | F | 7.59 | pEC50 | 26 | nM | EC50 | J Med Chem (2019) 62: 6137-6145 [PMID:31177777] |
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta2 proteasome A117D mutant measured after 72 hrs by SYBR green dye based fluorescence assay | F | 8.14 | pEC50 | 7.3 | nM | EC50 | J Med Chem (2019) 62: 6137-6145 [PMID:31177777] |
| proteasome 20S subunit beta 5 in Human [GtoPdb: 2406] [UniProtKB: P28074] | ||||||||
| GtoPdb | - | - | 6 | pIC50 | 1000 | nM | IC50 | Nature (2016) 530: 233-6 [PMID:26863983] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum [GtoPdb: 3088] | ||||||||
| GtoPdb | - | - | 6.1 | pIC50 | 800 | nM | IC50 | Nature (2016) 530: 233-6 [PMID:26863983] |
| GtoPdb | Parasite growth inhibition assay | - | 8.22 | pEC50 | 6 | nM | EC50 | J Am Chem Soc (2018) 140: 11424-11437 [PMID:30107725] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
