GC-373   Click here for help

GtoPdb Ligand ID: 11635

Synonyms: GC373 | N-benzyloxycarbonyl-L-leucyl-3-(2-oxopyrrolidin-3-yl)-L-alaninal
Compound class: Peptide
Comment: GC-373 is the parent of the dipeptide-based prodrug GC-376. The aldehyde drug and bisulphite adduct prodrug were originally reported as inhibitors of the 3CL protease (Mpro) of feline coronaviruses and caliciviruses [1]. They also inhibit Mpro of both SARS-CoV and SARS-CoV-2, and inhibit SARS-CoV-2 replication in cell culture [3].
Click here for help
2D Structure
Click here for help
Click here for structure editor
Click here for help
Canonical SMILES O=C[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(C)C)CC1CCNC1=O
Isomeric SMILES O=C[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(C)C)CC1CCNC1=O
InChI InChI=1S/C21H29N3O5/c1-14(2)10-18(24-21(28)29-13-15-6-4-3-5-7-15)20(27)23-17(12-25)11-16-8-9-22-19(16)26/h3-7,12,14,16-18H,8-11,13H2,1-2H3,(H,22,26)(H,23,27)(H,24,28)/t16?,17-,18-/m0/s1
Classification Click here for help
Compound class Peptide
Synonyms Click here for help
GC373 | N-benzyloxycarbonyl-L-leucyl-3-(2-oxopyrrolidin-3-yl)-L-alaninal
Database Links Click here for help
CAS Registry No. 1333231-44-9 (source: PubChem)
ChEMBL Ligand CHEMBL1821850
GtoPdb PubChem SID 442878665
PubChem CID 54752934
Search Google for chemical match using the InChIKey QYENXTYKACLCGO-FQECFTEESA-N
Search Google for chemicals with the same backbone QYENXTYKACLCGO
UniChem Compound Search for chemical match using the InChIKey QYENXTYKACLCGO-FQECFTEESA-N
UniChem Connectivity Search for chemical match using the InChIKey QYENXTYKACLCGO-FQECFTEESA-N