N-acetylserotonin [Ligand Id: 5451] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL33103 (N-Acetylserotonin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] | ||||||||
| ChEMBL | Positive allosteric modulation of recombinant human IDOL transfected in mouse P1.HTR cells assessed as increase in Kyn production incubated for 24 hrs | B | 4.71 | pEC50 | 19560 | nM | EC50 | RSC Med Chem (2023) 14: 2206-2230 [PMID:37974956] |
| indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075294] [GtoPdb: 2829] [UniProtKB: P28776] | ||||||||
| ChEMBL | Positive allosteric modulation of recombinant mouse IDOL transfected in mouse P1.HTR cells assessed as increase in Kyn production incubated for 24 hrs | B | 4.68 | pEC50 | 20950 | nM | EC50 | RSC Med Chem (2023) 14: 2206-2230 [PMID:37974956] |
| Palmitoleoyl-protein carboxylesterase NOTUM in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714531] [UniProtKB: Q6P988] | ||||||||
| ChEMBL | Inhibition of human Notum using OPTS substrate by fluorescence based assay | B | 4.03 | pIC50 | 93600 | nM | IC50 | J Med Chem (2021) 64: 4289-4311 [PMID:33783220] |
| sepiapterin reductase/Sepiapterin reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988583] [GtoPdb: 3020] [UniProtKB: P35270] | ||||||||
| ChEMBL | Inhibition of human sepiapterin reductase using L-sepiapterin as substrate preincubated for 15 mins followed by substrate addition | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2019) 62: 6391-6397 [PMID:31244106] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
