N-acetylserotonin [Ligand Id: 5451] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL33103 (N-Acetylserotonin)
  • Palmitoleoyl-protein carboxylesterase NOTUM in Human [ChEMBL: CHEMBL3714531] [UniProtKB: Q6P988]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Palmitoleoyl-protein carboxylesterase NOTUM in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714531] [UniProtKB: Q6P988]
ChEMBL Inhibition of human Notum using OPTS substrate by fluorescence based assay B 4.03 pIC50 93600 nM IC50 J Med Chem (2021) 64: 4289-4311 [PMID:33783220]
sepiapterin reductase/Sepiapterin reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988583] [GtoPdb: 3020] [UniProtKB: P35270]
ChEMBL Inhibition of human sepiapterin reductase using L-sepiapterin as substrate preincubated for 15 mins followed by substrate addition B 5.3 pIC50 5000 nM IC50 J Med Chem (2019) 62: 6391-6397 [PMID:31244106]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]