M-CSF   Click here for help

GtoPdb Ligand ID: 4905

Synonyms: CSF-1 | lanimostim | macrophage-CSF
Immunopharmacology Ligand
Comment: M-CSF (CSF1) controls survival and differentiation of macrophages via activation of the CSF1 receptor (a receptor tyrosine kinase). The biologically active peptide is a homodimer or a heterodimer.
Pharmacological modulators of the CSF1/CSF1R axis, targeting tumour-associated macrophage (TAM) survival, are being developed for various solid tumour and hematological oncology indications as well as for autoimmune diseases.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
CSF-1 | lanimostim | macrophage-CSF
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CSF1 colony stimulating factor 1 Human prepro-macrophage colony stimulating factor 1 colony stimulating factor 1 (macrophage), M-CSF, MCSF, MGC31930
Database Links Click here for help
Ensembl Gene ENSG00000184371 (Hs)
GtoPdb PubChem SID 178101604
Human Protein Atlas ENSG00000184371 (Hs)
UniProtKB P09603 (Hs)
Wikipedia CSF1