Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL240597 (Chenodeoxycholate, NSC-657949, Combidol, Xenbilox, Chenodeoxycholic acid, Chenofalk, Chenix, Chenic acid, Lithofalk, Chenodiol, Chendol 125, Chendol 250, Chenocedon) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Bile acid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5343] [UniProtKB: Q60641] | ||||||||
ChEMBL | Agonist activity at mouse FXR expressed in HEK293 cells co-expressing mouse RXRalpha and ECRE-luc by luciferase reporter gene assay | F | 4.77 | pEC50 | 16800 | nM | EC50 | Bioorg. Med. Chem. (2011) 19: 7168-7180 [PMID:22018919] |
Farnesoid X receptor/Bile acid receptor FXR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1] | ||||||||
ChEMBL | Activation of human farnesoid X receptor; range is 10-30 | B | 4.52 | pEC50 | 30000 | nM | EC50 | J. Med. Chem. (2005) 48: 5383-5403 [PMID:16107136] |
ChEMBL | Agonist activity at human recombinant FXR expressed in HEK293 cells coexpressing CMX-GAL4N by luciferase reporter gene assay | F | 4.57 | pEC50 | 27000 | nM | EC50 | Bioorg. Med. Chem. Lett. (2012) 22: 3962-3966 [PMID:22583617] |
ChEMBL | Agonistic activity at FXR in HEK293 cells by GAL4 transactivation activity | F | 4.57 | pEC50 | 27000 | nM | EC50 | Bioorg. Med. Chem. (2007) 15: 2587-2600 [PMID:17292610] |
ChEMBL | Agonist activity at human GST-fused FXR LBD assessed as coactivator interaction with receptor ligand binding domain by Alphascreen assay | B | 4.68 | pEC50 | 21000 | nM | EC50 | Bioorg. Med. Chem. (2011) 19: 2650-2658 [PMID:21459580] |
ChEMBL | Transactivation of human FXR (unknown origin) expressed in HepG2 cells co-expressing pSG5RXR/pGL4.70 after 24 hrs post transfection by luciferase reporter gene assay | B | 4.7 | pEC50 | 20000 | nM | EC50 | ACS Med Chem Lett (2019) 10: 407-412 [PMID:30996771] |
ChEMBL | Agonist activity at human full length FXR expressed in HeLa cells cotransfected with pSG5-human RXR after 24 hrs by Dual-Glo luciferase reporter gene assay | B | 4.74 | pEC50 | 18000 | nM | EC50 | Bioorg. Med. Chem. (2015) 23: 3490-3498 [PMID:25934227] |
ChEMBL | Agonist activity at farnesoid x receptor(unknown origin) | B | 4.74 | pEC50 | 18000 | nM | EC50 | Bioorg. Med. Chem. (2016) 24: 3232-3245 [PMID:27240466] |
ChEMBL | Agonist activity at human FXR expressed in human HeLa cells assessed as receptor activation by BSEP promoter-driven firefly luciferase reporter gene assay | B | 4.74 | pEC50 | 18000 | nM | EC50 | J. Med. Chem. (2014) 57: 8035-8055 [PMID:25255039] |
ChEMBL | Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assay | B | 4.82 | pEC50 | 15000 | nM | EC50 | Eur J Med Chem (2018) 144: 349-358 [PMID:29275233] |
ChEMBL | Agonist activity at FXR (unknown origin) | B | 4.89 | pEC50 | 13000 | nM | EC50 | Bioorg. Med. Chem. (2016) 24: 3986-3993 [PMID:27372840] |
ChEMBL | Agonist activity at human FXR expressed in COS1 cells by luciferase assay | F | 4.89 | pEC50 | 13000 | nM | EC50 | J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294] |
ChEMBL | Agonist activity at human FXR expressed in COS1 cells after 5 hrs by CRE-driven luciferase reporter gene assay | F | 4.89 | pEC50 | 13000 | nM | EC50 | J. Med. Chem. (2007) 50: 4265-4268 [PMID:17685603] |
ChEMBL | Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assay | F | 4.89 | pEC50 | 13000 | nM | EC50 | J. Med. Chem. (2009) 52: 7958-7961 [PMID:20014870] |
ChEMBL | Agonist activity at GST-tagged FXR-LBD using biotinylated-SRC-1 peptide as substrate preincubated with compound for 30 mins measured after 4 hrs | F | 4.89 | pEC50 | 13000 | nM | EC50 | ACS Med. Chem. Lett. (2012) 3: 273-277 [PMID:24900463] |
ChEMBL | Agonist activity at human recombinant FXR by transactivation of TK-MH100x4-LUC reporter gene in HEK293 cells | F | 4.93 | pEC50 | 11700 | nM | EC50 | Bioorg. Med. Chem. Lett. (2006) 16: 3213-3218 [PMID:16617018] |
ChEMBL | Agonist activity at FXR | F | 5 | pEC50 | 10000 | nM | EC50 | Bioorg. Med. Chem. (2011) 19: 6779-6791 [PMID:22014750] |
ChEMBL | Agonist activity at FXR (unknown origin) assessed as recruitment of SRC1 peptide to FXR by FRET assay | B | 5.05 | pEC50 | 9000 | nM | EC50 | J Med Chem (2017) 60: 5235-5266 [PMID:28252961] |
ChEMBL | Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assay | F | 5.06 | pEC50 | 8660 | nM | EC50 | J. Med. Chem. (2006) 49: 4208-4215 [PMID:16821780] |
ChEMBL | Effective concentration against Farnesoid X receptor (FXR) | B | 5.06 | pEC50 | 8660 | nM | EC50 | J. Med. Chem. (2002) 45: 3569-3572 [PMID:12166927] |
ChEMBL | Binding affinity for human Farnesoid X receptor in FRET assay | B | 5.06 | pEC50 | 8660 | nM | EC50 | J. Med. Chem. (2004) 47: 4559-4569 [PMID:15317466] |
ChEMBL | Agonist activity at human FXR assessed as recruitment of SRC1 peptide by TR-FRET assay | B | 5.06 | pEC50 | 8660 | nM | EC50 | ACS Med Chem Lett (2017) 8: 1246-1251 [PMID:29259742] |
ChEMBL | Agonist activity at FXR (unknown origin) | B | 5.06 | pEC50 | 8660 | nM | EC50 | J Med Chem (2020) 63: 5031-5073 [PMID:31930920] |
ChEMBL | Binding affinity for Farnesoid X Receptor (FXR) | B | 5.06 | pEC50 | 8660 | nM | EC50 | Bioorg. Med. Chem. Lett. (2003) 13: 1865-1868 [PMID:12749886] |
ChEMBL | Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotinylated SRC-1 recruitment after 30 mins by Alpha Screen assay | B | 5.1 | pEC50 | 8000 | nM | EC50 | MedChemComm (2019) 10: 1412-1419 |
ChEMBL | Transactivation of full-length FXR (unknown origin) expressed in HEK293 cells after 18 hrs by dual-glo luciferase reporter gene assay | B | 5.15 | pEC50 | 7010 | nM | EC50 | MedChemComm (2018) 9: 1630-1638 |
ChEMBL | Agonist activity at FXR assessed as activation by cell based luciferase transactivation assay | F | 5.2 | pEC50 | 6310 | nM | EC50 | Bioorg. Med. Chem. Lett. (2008) 18: 5497-5502 [PMID:18815030] |
GtoPdb | - | - | 5.3 | pEC50 | - | - | - |
Science (1999) 284: 1365-8 [PMID:10334993]; Mol Cell (1999) 3: 543-53 [PMID:10360171] |
ChEMBL | Effective concentration for recruitment of SRC-1 LxxLL-containing peptide to human Farnesoid X receptor | B | 5.46 | pEC50 | 3500 | nM | EC50 | J. Med. Chem. (2005) 48: 5383-5403 [PMID:16107136] |
ChEMBL | Ligand dependent recruitment of SRC1(676-700) peptide to human Farnesoid X-activated receptor by fluorescence resonance energy transfer assay | B | 5.47 | pEC50 | 3400 | nM | EC50 | J. Med. Chem. (2000) 43: 2971-2974 [PMID:10956205] |
Retinoid X receptor-α/Bile acid receptor/Retinoic acid receptor RXR-alpha in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885529] [GtoPdb: 610] [UniProtKB: P28700, Q60641] | ||||||||
ChEMBL | Agonist activity at full length mouse FXR/RXRalpha expressed in human HEK293 cells assessed as induction of transcriptional activity after 18 hrs by dual luciferase reporter gene assay | F | 4.77 | pEC50 | 16800 | nM | EC50 | Bioorg. Med. Chem. (2011) 19: 6779-6791 [PMID:22014750] |
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] | ||||||||
ChEMBL | Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay | B | 4.48 | pEC50 | 33000 | nM | EC50 | J Med Chem (2019) 62: 6824-6830 [PMID:31268316] |
ChEMBL | Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay | F | 4.52 | pEC50 | 30000 | nM | EC50 | Bioorg. Med. Chem. (2011) 19: 2650-2658 [PMID:21459580] |
ChEMBL | Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay | B | 4.81 | pEC50 | 15600 | nM | EC50 | J Med Chem (2019) 62: 6824-6830 [PMID:31268316] |
ChEMBL | Agonist activity at wild type TGR5 (unknown origin) | B | 4.99 | pEC50 | 10290 | nM | EC50 | ACS Med. Chem. Lett. (2013) 4: 1158-1162 [PMID:24900622] |
ChEMBL | Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay | F | 5.17 | pEC50 | 6710 | nM | EC50 | J. Med. Chem. (2007) 50: 4265-4268 [PMID:17685603] |
ChEMBL | Agonist activity at human TGR5 expressed in CHO cells by luciferase assay | F | 5.17 | pEC50 | 6710 | nM | EC50 | J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294] |
ChEMBL | Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis | F | 5.17 | pEC50 | 6700 | nM | EC50 | ACS Med. Chem. Lett. (2012) 3: 273-277 [PMID:24900463] |
ChEMBL | Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay | B | 5.21 | pEC50 | 6100 | nM | EC50 | Bioorg. Med. Chem. (2015) 23: 1613-1628 [PMID:25735208] |
GtoPdb | - | - | 5.4 | pEC50 | - | - | - | Biochem Biophys Res Commun (2002) 298: 714-9 [PMID:12419312] |
Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells | F | 5.48 | pKi | 3300 | nM | Ki | Am. J. Physiol. (1998) 274: G157-G169 [PMID:9458785] |
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay | F | 4.72 | pIC50 | 18900 | nM | IC50 | Eur. J. Med. Chem. (2015) 100: 10-17 [PMID:26063305] |
Vitamin D receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1977] [GtoPdb: 605] [UniProtKB: P11473] | ||||||||
ChEMBL | Antagonist activity against VP16 tagged-VDR-LBD (unknown origin) expressed in HEK293T cells assessed as inhibition of 1,25-dihydroxyvitamin D3-induced SRC1 coactivator peptide recruitment after 16 hrs by luciferase reporter gene based two hybrid assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | Eur. J. Med. Chem. (2016) 109: 238-246 [PMID:26774929] |
FPR1 in Human [GtoPdb: 222] [UniProtKB: P21462] | ||||||||
GtoPdb | - | - | 4 | pKi | - | - | - | Inflamm Res (2000) 49: 744-55 [PMID:11211928] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]