Synonyms: TL-895 | TL895
Compound class:
Synthetic organic
Comment: Example A225 [WO2012170976A2] is an investigational Bruton's tyrosine kinase (BTK) inhibitor. It is a fluoropiperidin analogue of evobrutinib and its chemical structure is claimed in Merck patent. This compound has been identified as TL-895 by online chemical resources, in which it is described as an orally-available, selective and irreversible BTK inhibitor. TL-895 was originally developed for potential to treat refractory myelofibrosis and acute myeloid leukemia (AML).
COVID-19: TL-895 has been redeployed for anti-inflammatory potential in COVID-19 patients. BTK inhibition is expected to reduce production of pro-inflammatory cytokines that are associated with cytokine storm, disease progression and poor prognosis in hospitalised COVID-19 patients. ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]-4-fluoropiperidin-1-yl]prop-2-en-1-one |
Synonyms ![]() |
TL-895 | TL895 |
Database Links ![]() |
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BindingDB Ligand | 291505 |
GtoPdb PubChem SID | 464244124 |
PubChem CID | 86721856 |
Search Google for chemical match using the InChIKey | OXOXFDSEGFLWLU-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | OXOXFDSEGFLWLU |
UniChem Compound Search for chemical match using the InChIKey | OXOXFDSEGFLWLU-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | OXOXFDSEGFLWLU-UHFFFAOYSA-N |