AS99 [Ligand Id: 383] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL33491 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine receptor A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| GtoPdb | - | - | 6.1 | pKi | - | - | - | Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300] |
| ChEMBL | Displacement of specific [3H]DPCPX binding at human adenosine A1 receptor expressed in CHO cells | B | 6.15 | pKi | 700 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| A2A receptor/Adenosine receptor A2a in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Binding affinity of compound for displacement of specific [3H]ZM-241385 binding at human adenosine A2A receptor expressed in CHO cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| A2B receptor/Adenosine receptor A2b in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| ChEMBL | Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| GtoPdb | - | - | 8.4 | pKi | - | - | - | Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300] |
| ChEMBL | Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor | F | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| A3 receptor/Adenosine receptor A3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Binding affinity of compound for displacement of specific [3H]MRE3008-F20 binding at human A3 receptors expressed in CHO cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
