2-Methoxyestradiol [Ligand Id: 12058] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL299613 (2-methoxyestradiol, 2-methoxyoestradiol, NSC-659853) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP1B1/Cytochrome P450 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4878] [GtoPdb: 1320] [UniProtKB: Q16678] | ||||||||
| ChEMBL | Inhibition of recombinant CYP1B1 (unknown origin) expressed in Escherichia coli DH5alphaF'Iq coexpressing human NADPH-P450 reductase using E2-d4 as substrate after 10 mins in presence of NADP+ | B | 4.44 | pKi | 36000 | nM | Ki | Eur J Med Chem (2017) 135: 296-306 [PMID:28458135] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278] | ||||||||
| ChEMBL | Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin | B | 9.08 | pKd | 0.83 | nM | Kd | J Med Chem (2008) 51: 2047-2056 [PMID:18330978] |
| Tubulin in Bovine (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111464] [UniProtKB: Q6B856, Q862F3] | ||||||||
| ChEMBL | Inhibition of polymerization of purified bovine tubulin | F | 5.85 | pIC50 | 1400 | nM | IC50 | J Med Chem (2000) 43: 2419-2429 [PMID:10882369] |
| Tubulin beta chain in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3394] [UniProtKB: Q6B856] | ||||||||
| ChEMBL | Inhibitory concentration against bovine brain tubulin polymerization | F | 5.28 | pIC50 | 5300 | nM | IC50 | J Med Chem (2004) 47: 5126-5139 [PMID:15456256] |
| ChEMBL | In vitro inhibition of tubulin polymerization. | B | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (1995) 38: 2041-2049 [PMID:7783135] |
| GPER in Human [GtoPdb: 221] [UniProtKB: Q99527] | ||||||||
| GtoPdb | Specific binding affinity of [3H]2ME2 to GPER in vitro | - | 8 | pKd | 10 | nM | Kd | Eur J Pharmacol (2014) 723: 131-40 [PMID:24262995] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
