xanthine [Ligand Id: 4557] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1424 (Xanthine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method | B | 5.05 | pIC50 | 9000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4336-4341 [PMID:23791077] |
| A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (1992) 35: 4039-4044 [PMID:1331453] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4336-4341 [PMID:23791077] |
| Guanine deaminase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3129] [UniProtKB: Q9Y2T3] | ||||||||
| ChEMBL | Inhibition of GDA by colorimetric assay | B | 5.71 | pKi | 1960 | nM | Ki | Bioorg Med Chem (2010) 18: 6748-6755 [PMID:20716488] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
