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Synonyms: BPS 804 | BPS804
Compound class: Antibody
Comment: BPS-804 is a fully human investigational monoclonal antibody targeting sclerostin (SOST), being developed by Mereo BioPharma and which is designed to improve bone density. BPS-804 is one of the clinical assets acquired from Novartis, in exchange for equity in Mereo BioPharma.
Development of anti-sclerostin antibodies by Novartis is claimed in patent WO2009047356 , although we cannot definitively conclude that BPS-804 is claimed within that patent application.
The potential of sclerostin as a therapeutic target in bone diseases is reviewed by Lewiecki (2014) .