S9947 [Ligand Id: 2562] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL148159 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| K2P3.1/Potassium channel subfamily K member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321613] [GtoPdb: 515] [UniProtKB: O14649] | ||||||||
| ChEMBL | Inhibition of human TASK1 expressed in Xenopus oocytes by whole cell voltage clamp assay | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
| Kv1.3/Voltage-gated potassium channel subunit Kv1.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4633] [GtoPdb: 540] [UniProtKB: P22001] | ||||||||
| ChEMBL | Inhibition of human voltage-gated potassium channel subunit Kv1.3 expressed in Xenopus oocytes | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2003) 46: 486-498 [PMID:12570371] |
| Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| ChEMBL | Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2003) 46: 486-498 [PMID:12570371] |
| GtoPdb | - | - | 6.4 | pIC50 | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2002) 366: 482-7 [PMID:12382079]; Naunyn Schmiedebergs Arch Pharmacol (2001) 364: 472-8 [PMID:11692231] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
