compound 17 [PMID: 23570514] [Ligand Id: 8778] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2332041
  • sirtuin 1/NAD-dependent deacetylase sirtuin 1 in Human [ChEMBL: CHEMBL4506] [GtoPdb: 2707] [UniProtKB: Q96EB6]
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  • sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6]
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  • sirtuin 3/NAD-dependent deacetylase sirtuin 3 in Human [ChEMBL: CHEMBL4461] [GtoPdb: 2709] [UniProtKB: Q9NTG7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
sirtuin 1/NAD-dependent deacetylase sirtuin 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4506] [GtoPdb: 2707] [UniProtKB: Q96EB6]
GtoPdb - - 8.17 pIC50 6.7 nM IC50 J. Med. Chem. (2013) 56: 3666-79 [PMID:23570514]
ChEMBL Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after 30 mins by mass spectrophotometric analysis B 8.17 pIC50 6.7 nM IC50 J. Med. Chem. (2013) 56: 3666-3679 [PMID:23570514]
sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6]
GtoPdb - - 8.74 pIC50 1.8 nM IC50 J. Med. Chem. (2013) 56: 3666-79 [PMID:23570514]
ChEMBL Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrate addition measured after 30 mins by mass spectrophotometric analysis B 8.74 pIC50 1.8 nM IC50 J. Med. Chem. (2013) 56: 3666-3679 [PMID:23570514]
sirtuin 3/NAD-dependent deacetylase sirtuin 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4461] [GtoPdb: 2709] [UniProtKB: Q9NTG7]
GtoPdb - - 8.49 pIC50 3.2 nM IC50 J. Med. Chem. (2013) 56: 3666-79 [PMID:23570514]
ChEMBL Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after 30 mins by mass spectrophotometric analysis B 8.49 pIC50 3.2 nM IC50 J. Med. Chem. (2013) 56: 3666-3679 [PMID:23570514]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]