ChEMBL ligand: CHEMBL2425612
beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] There should be some charts here, you may need to enable JavaScript!
cathepsin D/Cathepsin D in Human [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL	Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing wild type APP	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2013) 23: 5300-5306 [PMID:23981898]
ChEMBL	Inhibition of human BACE1	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2013) 23: 5300-5306 [PMID:23981898]
GtoPdb	-	-	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2013) 23: 5300-6 [PMID:23981898]
cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339]
ChEMBL	Inhibition of human cathepsin-D	B	6.09	pIC50	820	nM	IC50	Bioorg Med Chem Lett (2013) 23: 5300-5306 [PMID:23981898]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]