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ChEMBL ligand: CHEMBL461139 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Inhibition of Alk | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
ChEMBL | Inhibition of JNK1 | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
ChEMBL | Inhibition of JNK2 | B | 6.02 | pIC50 | 950 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764] | ||||||||
ChEMBL | Inhibition of EphA4 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] | ||||||||
ChEMBL | Inhibition of EphB4 | B | 5.77 | pIC50 | 1700 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of HER1 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455] | ||||||||
ChEMBL | Inhibition of FGFR4 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3b | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
GtoPdb | - | - | 7.07 | pIC50 | 85 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6 [PMID:18945615] |
ChEMBL | Inhibition of c-Met | B | 7.07 | pIC50 | 85 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
ChEMBL | Inhibition of IGF1R | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of Ins1R | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
GtoPdb | - | - | 7.29 | pIC50 | 51 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6 [PMID:18945615] |
ChEMBL | Inhibition of human MK2 | B | 7.29 | pIC50 | 51 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
ChEMBL | Inhibition of MK5 | B | 7.62 | pIC50 | 24 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
GtoPdb | - | - | 7.62 | pIC50 | 24 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6 [PMID:18945615] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
ChEMBL | Inhibition of PDK1 | B | 5.66 | pIC50 | 2200 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
ChEMBL | Inhibition of PDGFRa | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
ChEMBL | Inhibition of HER2 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of PKB | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
GtoPdb | - | - | 7.03 | pIC50 | 93 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6 [PMID:18945615] |
ChEMBL | Inhibition of Aurora A | B | 7.03 | pIC50 | 93 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Inhibition of c-Kit | B | 5.28 | pIC50 | 5200 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
ChEMBL | Inhibition of Btk | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 | B | 6.51 | pIC50 | 310 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of Lck | B | 5.22 | pIC50 | 6000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
ChEMBL | Inhibition of Syk | B | 5.21 | pIC50 | 6200 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of KDR | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6142-6146 [PMID:18945615] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]