hydromorphone [Ligand Id: 7082] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL398707 (Dilaudid, Dilaudid-HP, Dimorphone, Hydromorphon, Hydromorphone, IDS-NH-004, Jurnista, N02AA03, Novolaudon, NSC-19046, Palladone) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| GtoPdb | - | - | 7.42 | pKi | 38 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2289-94 [PMID:19282177] |
| ChEMBL | Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting | B | 7.42 | pKi | 38 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| GtoPdb | - | - | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2289-94 [PMID:19282177] |
| ChEMBL | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting | B | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177] |
| ChEMBL | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 7.96 | pEC50 | 11 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| GtoPdb | - | - | 9.55 | pKi | 0.28 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2289-94 [PMID:19282177] |
| ChEMBL | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting | B | 9.55 | pKi | 0.28 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177] |
| ChEMBL | Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 8.59 | pEC50 | 2.6 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
