PPADS [Ligand Id: 1725] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL69234
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Rat [ChEMBL: CHEMBL4295913] [UniProtKB: Q924C3]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • P2Y1 receptor/Purinergic receptor P2Y1 in Human [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900]
There should be some charts here, you may need to enable JavaScript!
  • P2Y12 receptor/Purinergic receptor P2Y12 in Rat [ChEMBL: CHEMBL2188] [GtoPdb: 328] [UniProtKB: Q9EPX4]
There should be some charts here, you may need to enable JavaScript!
  • P2Y2 receptor/Purinergic receptor P2Y2 in Human [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
There should be some charts here, you may need to enable JavaScript!
  • P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582]
There should be some charts here, you may need to enable JavaScript!
  • P2Y6 receptor in Human [GtoPdb: 326] [UniProtKB: Q15077]
There should be some charts here, you may need to enable JavaScript!
  • P2Y13 receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295913] [UniProtKB: Q924C3]
ChEMBL Inhibition of NPP1 in Wistar rat C6 cells using [gamma-32P]ATP as substrate pretreated for 30 mins followed by substrate addition and measured after 90 mins by TLC analysis B 4.92 pIC50 12000 nM IC50 MedChemComm (2017) 8: 823-840
P2X1/P2X purinoceptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5496] [GtoPdb: 478] [UniProtKB: P51576]
ChEMBL Antagonist activity at mouse P2X1 receptor B 7 pIC50 99 nM IC50 Eur. J. Med. Chem. (2013) 70: 811-830 [PMID:24246730]
P2X1/P2X purinoceptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2530] [GtoPdb: 478] [UniProtKB: P47824]
ChEMBL Compound was tested in a functional ion channel assay of ATP-induced current at recombinant rat P2X1 receptor expressed in Xenopus oocytes. B 4.01 pIC50 98500 nM IC50 J. Med. Chem. (1998) 41: 2201-2206 [PMID:9632352]
ChEMBL Inhibition of inward ion current elicited by ATP at P2X1 receptor expressed in Xenopus oocytes F 7 pIC50 99 nM IC50 J. Med. Chem. (2001) 44: 340-349 [PMID:11462975]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 1 (P2X1) at 1 uM, expressed in Xenopus oocytes F 7 pEC50 99 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X2/P2X purinoceptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2135] [GtoPdb: 479] [UniProtKB: P49653]
ChEMBL Inhibition of inward ion current elicited by ATP at P2X2 receptor expressed in Xenopus oocytes F 5.8 pIC50 1600 nM IC50 J. Med. Chem. (2001) 44: 340-349 [PMID:11462975]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 30 uM, expressed in Xenopus oocytes F 4.92 pEC50 12000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X3/P2X purinoceptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2998] [GtoPdb: 480] [UniProtKB: P56373]
ChEMBL Antagonist activity at human P2X3 receptor B 6.62 pIC50 240 nM IC50 Eur. J. Med. Chem. (2013) 70: 811-830 [PMID:24246730]
ChEMBL Antagonist activity against recombinant human P2X purinoceptor 3 (P2X3 ) F 5.77 pEC50 1700 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytes F 6.62 pEC50 240 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X3/P2X purinoceptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654]
ChEMBL Inhibition of inward ion current elicited by ATP was determined at recombinant P2X3 receptor expressed in Xenopus oocytes F 6.62 pIC50 240 nM IC50 J. Med. Chem. (2001) 44: 340-349 [PMID:11462975]
P2X4/P2X purinoceptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2104] [GtoPdb: 481] [UniProtKB: Q99571]
ChEMBL Inhibition of inward ion current elicited by ATP at human P2X4 receptor (mutant type) F 4.56 pIC50 27500 nM IC50 J. Med. Chem. (2001) 44: 340-349 [PMID:11462975]
ChEMBL Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4) F 5 pEC50 10000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X4/P2X purinoceptor 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176849] [GtoPdb: 481] [UniProtKB: Q9JJX6]
ChEMBL Inhibition of inward ion current elicited by ATP at mouse P2X4 receptor (mutant type) F 4.68 pIC50 21000 nM IC50 J. Med. Chem. (2001) 44: 340-349 [PMID:11462975]
P2X4/P2X purinoceptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2818] [GtoPdb: 481] [UniProtKB: P51577]
ChEMBL Inhibition of inward ion current elicited by ATP at rat P2X4 receptor (mutant type) F 5.59 pIC50 2600 nM IC50 J. Med. Chem. (2001) 44: 340-349 [PMID:11462975]
ChEMBL Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytes F 5 pEC50 >10000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X5/P2X purinoceptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2495] [GtoPdb: 482] [UniProtKB: P51578]
ChEMBL Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5) F 5.59 pEC50 2600 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X6/P2X purinoceptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2122] [GtoPdb: 483] [UniProtKB: P51579]
ChEMBL Inhibition of inward ion current elicited by ATP at rat P2X6 receptor (mutant type) F 5.7 pIC50 2000 nM IC50 J. Med. Chem. (2001) 44: 340-349 [PMID:11462975]
ChEMBL Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 ) F 4 pEC50 >100000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X7/P2X purinoceptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4805] [GtoPdb: 484] [UniProtKB: Q99572]
ChEMBL Antagonist activity at recombinant human P2X7 receptor assessed as inhibition of BzATP-mediated Yo-Pro uptake measured for 1 hr by FLIPR assay B 5.93 pIC50 1180 nM IC50 Eur. J. Med. Chem. (2013) 70: 811-830 [PMID:24246730]
P2X7/P2X purinoceptor 7 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2496] [GtoPdb: 484] [UniProtKB: Q64663]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 7 (P2X7) F 4.21 pEC50 62000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652]
ChEMBL Inhibition of 10 nM 2-MeS-ADP-stimulated phospholipase C in turkey erythrocyte membranes using [3H]inositol F 4.78 pIC50 16600 nM IC50 J. Med. Chem. (2001) 44: 340-349 [PMID:11462975]
P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900]
GtoPdb - - 5.2 pKi - - - Mol. Pharmacol. (2002) 62: 1249-57 [PMID:12391289]
ChEMBL Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of rat erythrocytes F 4.74 pEC50 18200 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
ChEMBL Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytes F 6 pEC50 1000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2Y12 receptor/Purinergic receptor P2Y12 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2188] [GtoPdb: 328] [UniProtKB: Q9EPX4]
ChEMBL Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) F 4 pEC50 >100000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
ChEMBL Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2) F 5 pEC50 >10000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582]
GtoPdb - - 5 pEC50 - - - Purinergic Signal. (2009) 5: 75-89 [PMID:18600475]
ChEMBL The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4) F 5 pEC50 >10000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2Y6 receptor in Human [GtoPdb: 326] [UniProtKB: Q15077]
P2Y13 receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8]
GtoPdb - - 4.9 pIC50 - - - Mol. Pharmacol. (2003) 64: 104-12 [PMID:12815166]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]