Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL315021 (Forasartan, SC-52458) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
ChEMBL | Antagonist activity at angiotensin AT1 receptor | F | 8.2 | pKd | 6.31 | nM | Kd | Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232] |
ChEMBL | Binding affinity to angiotensin AT1 receptor | B | 8.16 | pIC50 | 6.9 | nM | IC50 | Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232] |
AT1 receptor in Rat [GtoPdb: 34] [UniProtKB: P29089, P25095] | ||||||||
GtoPdb | - | - | 8.6 | pIC50 | 2.8 | nM | IC50 | J Cardiovasc Pharmacol (1993) 22: 617-25 [PMID:7505365] |
AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] | ||||||||
ChEMBL | Binding affinity for rat angiotensin II receptor, type 1 | B | 8.16 | pIC50 | 6.9 | nM | IC50 | J Med Chem (2004) 47: 2574-2586 [PMID:15115399] |
GtoPdb | - | - | 8.6 | pIC50 | 2.8 | nM | IC50 | J Cardiovasc Pharmacol (1993) 22: 617-25 [PMID:7505365] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]