AZD2927   Click here for help

GtoPdb Ligand ID: 7704

Synonyms: AZD 2927 | AZD-2927
Compound class: Synthetic organic
Comment: AZD2927 blocks the potassium channels Kir3.1/Kir3.4 which convey an inwardly rectifying potassium current (IKACh). AZD2927 was used as an investigative compound as a potential treatment for patients with atrial flutter, but efficacy was not shown. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 43.78
Molecular weight 308.19
XLogP 2.04
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES OC1CN(C1)CC(N(C(=O)c1ccc(c(c1)C)F)C)C(C)C
Isomeric SMILES OC1CN(C1)C[C@@H](N(C(=O)c1ccc(c(c1)C)F)C)C(C)C
InChI InChI=1S/C17H25FN2O2/c1-11(2)16(10-20-8-14(21)9-20)19(4)17(22)13-5-6-15(18)12(3)7-13/h5-7,11,14,16,21H,8-10H2,1-4H3/t16-/m1/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
Synonyms Click here for help
AZD 2927 | AZD-2927
Database Links Click here for help
GtoPdb PubChem SID 223366037
PubChem CID 57345449
Search Google for chemical match using the InChIKey GAHPWXLXWUVMIV-MRXNPFEDSA-N
Search Google for chemicals with the same backbone GAHPWXLXWUVMIV
UniChem Compound Search for chemical match using the InChIKey GAHPWXLXWUVMIV-MRXNPFEDSA-N
UniChem Connectivity Search for chemical match using the InChIKey GAHPWXLXWUVMIV-MRXNPFEDSA-N