AZD2927   

GtoPdb Ligand ID: 7704

Synonyms: AZD 2927 | AZD-2927
Compound class: Synthetic organic
Comment: AZD2927 blocks the potassium channels Kir3.1/Kir3.4 which convey an inwardly rectifying potassium current (IKACh). AZD2927 was used as an investigative compound as a potential treatment for patients with atrial flutter, but efficacy was not shown. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 43.78
Molecular weight 308.19
XLogP 2.04
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC1CN(C1)CC(N(C(=O)c1ccc(c(c1)C)F)C)C(C)C
Isomeric SMILES OC1CN(C1)C[C@@H](N(C(=O)c1ccc(c(c1)C)F)C)C(C)C
InChI InChI=1S/C17H25FN2O2/c1-11(2)16(10-20-8-14(21)9-20)19(4)17(22)13-5-6-15(18)12(3)7-13/h5-7,11,14,16,21H,8-10H2,1-4H3/t16-/m1/s1
InChI Key GAHPWXLXWUVMIV-MRXNPFEDSA-N
Bioactivity Comments
Pending publication, the data presented here are derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir3.1 Hs Channel blocker - 5.9 pIC50 - 1
pIC50 5.9 (IC50 1.3x10-6 M) [1]
Kir3.4 Hs Channel blocker - 5.9 pIC50 - 1
pIC50 5.9 (IC50 1.3x10-6 M) [1]