AZD2927   

GtoPdb Ligand ID: 7704

Synonyms: AZD 2927 | AZD-2927
Compound class: Synthetic organic
Comment: AZD2927 blocks the potassium channels Kir3.1/Kir3.4 which convey an inwardly rectifying potassium current (IKACh). AZD2927 was used as an investigative compound as a potential treatment for patients with atrial flutter, but efficacy was not shown. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 43.78
Molecular weight 308.19
XLogP 2.04
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC1CN(C1)CC(N(C(=O)c1ccc(c(c1)C)F)C)C(C)C
Isomeric SMILES OC1CN(C1)C[C@@H](N(C(=O)c1ccc(c(c1)C)F)C)C(C)C
InChI InChI=1S/C17H25FN2O2/c1-11(2)16(10-20-8-14(21)9-20)19(4)17(22)13-5-6-15(18)12(3)7-13/h5-7,11,14,16,21H,8-10H2,1-4H3/t16-/m1/s1
InChI Key GAHPWXLXWUVMIV-MRXNPFEDSA-N
Classification
Compound class Synthetic organic
IUPAC Name
4-fluoro-N-[(2S)-1-(3-hydroxyazetidin-1-yl)-3-methylbutan-2-yl]-N,3-dimethylbenzamide
Synonyms
AZD 2927 | AZD-2927
Database Links
GtoPdb PubChem SID 223366037
PubChem CID 57345449
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