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Synonyms: Boc-Gln-D-Trp(CH0)-Phe-OBzl | Nα-[Nα-[Nα-(tert-butyloxycabonyl)-L-glutaminyl]-N1-formyl-D-tryptophyl-L-phenylalanine benzyl ester
Compound class: Peptide or derivative
Comment: QWF was originally identified as a tripeptide derivative of the substance P-derived octapeptide and NK1 receptor selective antagonist D-Pro-Gln-Gln-D-TrpPhe-D-Trp-D-Trp-Phe-NH2 . It has more recently been reported to antagonise MRGPRX2 , and is claimed in patent WO2016118632 which covers the use of QWF derivatives as MRGPRX2 antagonists for the prevention and treatment of itch .