QWF

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Ligands
QWF

GtoPdb Ligand ID: 9568

Synonyms: Boc-Gln-D-Trp(CH0)-Phe-OBzl | N^α-[N^α-[N^α-(tert-butyloxycabonyl)-L-glutaminyl]-N¹-formyl-D-tryptophyl-L-phenylalanine benzyl ester

Compound class: Peptide or derivative

Comment: QWF was originally identified as a tripeptide derivative of the substance P-derived octapeptide and NK₁ receptor selective antagonist D-Pro-Gln-Gln-D-TrpPhe-D-Trp-D-Trp-Phe-NH₂ [2]. It has more recently been reported to antagonise MRGPRX2 [1], and is claimed in patent WO2016118632 which covers the use of QWF derivatives as MRGPRX2 antagonists for the prevention and treatment of itch [3].

Summary
Biological activity
References
Structure
Immunopharmacology

Immunopharmacology Comments
QWF antagonism of MRGPRX2 inhibits compound 48/80-induced degranulation of the LAD-2 human mast cell line and suppresses itch in vivo (albeit in a mouse model with no equivalent to a human disease) [1].

Immunopharmacology Comments

QWF antagonism of MRGPRX2 inhibits compound 48/80-induced degranulation of the LAD-2 human mast cell line and suppresses itch in vivo (albeit in a mouse model with no equivalent to a human disease) [1].