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ChEMBL ligand: CHEMBL63756 (Fluperlapine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
ChEMBL | Binding affinity against dopamine receptor D1 | B | 6.85 | pKi | 141.25 | nM | Ki | J Med Chem (1994) 37: 519-525 [PMID:7907148] |
ChEMBL | In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue | B | 6.85 | pKi | 141 | nM | Ki | J Med Chem (1993) 36: 2107-2114 [PMID:8101877] |
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
ChEMBL | In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue. | B | 6.88 | pKi | 133 | nM | Ki | J Med Chem (1993) 36: 2107-2114 [PMID:8101877] |
ChEMBL | Binding affinity against dopamine D2 receptor | B | 6.88 | pKi | 131.83 | nM | Ki | J Med Chem (1994) 37: 519-525 [PMID:7907148] |
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
GtoPdb | - | - | 7.5 | pKi | - | - | - |
J Neurochem (1996) 66: 47-56 [PMID:8522988]; Psychopharmacology (Berl) (2005) 179: 461-9 [PMID:15821958] |
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] | ||||||||
GtoPdb | - | - | 7.8 | pKi | - | - | - | J Pharmacol Exp Ther (1994) 268: 1403-10 [PMID:7908055] |
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
GtoPdb | - | - | 7.5 | pKi | - | - | - | Psychopharmacology (Berl) (2005) 179: 461-9 [PMID:15821958] |
5-HT7 receptor in Rat [GtoPdb: 12] [UniProtKB: P32305] | ||||||||
GtoPdb | - | - | 8.3 | pKi | - | - | - | J Pharmacol Exp Ther (1994) 268: 1403-10 [PMID:7908055] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]