pegaptanib   Click here for help

GtoPdb Ligand ID: 6836

Synonyms: EYEOO1 | Macugen® | NX183 | pegaptanib sodium
Approved drug
pegaptanib is an approved drug (FDA (2004), EMA (2006))
Compound class: Synthetic organic
Comment: Note that the PubChem CID listed here represents only the backbone of the molecule and does not include the RNA oligonucleotide aptamer attached to the phosphate group. Acts as a vascular endothelial growth factor A antagonist, anti-angiogenic agent.
Pegaptanib is a 28-mer RNA aptamer that is covalently linked to two branched 20-kD polyethylene glycol (PEG) chains.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 13
Hydrogen bond donors 4
Rotatable bonds 27
Topological polar surface area 180.56
Molecular weight 541.28
XLogP 0.58
No. Lipinski's rules broken 2
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InChI InChI=1S/C22H44N3O10P/c1-31-15-17-33-21(27)24-13-9-7-11-19(25-22(28)34-18-16-32-2)20(26)23-12-8-5-4-6-10-14-35-36(3,29)30/h19H,4-18H2,1-3H3,(H,23,26)(H,24,27)(H,25,28)(H,29,30)/t19-/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2004), EMA (2006))
IUPAC Name Click here for help
7-[[(2S)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid
International Nonproprietary Names Click here for help
INN number INN
8215 pegaptanib
Synonyms Click here for help
EYEOO1 | Macugen® | NX183 | pegaptanib sodium
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9679463
Reactome Reaction Reactome logo R-HSA-9679477
Other databases
CAS Registry No. 222716-86-1
DrugBank Ligand DB04895
GtoPdb PubChem SID 178103442
PubChem CID 56603655
Search Google for chemical match using the InChIKey WLCZTRVUXYALDD-IBGZPJMESA-N
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UniChem Compound Search for chemical match using the InChIKey WLCZTRVUXYALDD-IBGZPJMESA-N
UniChem Connectivity Search for chemical match using the InChIKey WLCZTRVUXYALDD-IBGZPJMESA-N
Wikipedia Pegaptanib