Compound class:
Synthetic organic
Comment: This compound is a bifunctional degrader of the cardiac-specific kinase TNNI3K protein, that is claimed in patent WO2021053495A1 (Preparation of Dihydropyrimidine Derivatives as Bifunctional Degraders for the Treatment and Prophylaxis of Target Protein-Mediated Diseases; Arista L et al., 2021). It's kinase binding domain is derived from the quinazoline TNNI3K inhibitor GSK114 [1], and it contains a cereblon binding ligand to promote association with the protein-degrading E3 ubiquitin ligase complex.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Database Links ![]() |
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GtoPdb PubChem SID | 458923842 |
PubChem CID | 156176504 |
Search Google for chemical match using the InChIKey | OGZQGEDLXOIYFN-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | OGZQGEDLXOIYFN |
Search UniChem for chemical match using the InChIKey | OGZQGEDLXOIYFN-UHFFFAOYSA-N |
Search UniChem for chemicals with the same backbone | OGZQGEDLXOIYFN |