Synonyms: compound 21 [WO2021053495A1]
Compound class:
Synthetic organic
Comment: This compound is a bifunctional degrader of the cardiac-specific kinase TNNI3K protein, that is claimed in patent WO2021053495A1 [1]. It's kinase binding domain is derived from the quinazoline TNNI3K inhibitor GSK114 [2], and it contains a cereblon binding ligand to promote association with the protein-degrading E3 ubiquitin ligase complex.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
4-(dimethylamino)-3-[[7-[3-[4-[4-[4-[4-(2,4-dioxo-1,3-diazinan-1-yl)phenyl]but-3-ynyl]piperazine-1-carbonyl]piperazin-1-yl]propoxy]quinazolin-4-yl]amino]-N-methylbenzenesulfonamide |
Synonyms ![]() |
compound 21 [WO2021053495A1] |
Database Links ![]() |
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GtoPdb PubChem SID | 458923842 |
PubChem CID | 156176504 |
Search Google for chemical match using the InChIKey | OGZQGEDLXOIYFN-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | OGZQGEDLXOIYFN |
UniChem Compound Search for chemical match using the InChIKey | OGZQGEDLXOIYFN-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | OGZQGEDLXOIYFN-UHFFFAOYSA-N |