UDP [Ligand Id: 1749] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL130266 (UDP, Uridine 5'-Diphosphate, Uridine-5'-Diphosphate, Uridine Diphosphate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
| ChEMBL | Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytes | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| P2Y14 receptor/Purinergic receptor P2Y14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391] | ||||||||
| ChEMBL | Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production | F | 6.8 | pEC50 | 160 | nM | EC50 | J Med Chem (2010) 53: 471-480 [PMID:19902968] |
| ChEMBL | Agonist activity at human recombinant P2Y14 receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation proximity assay | F | 6.8 | pEC50 | 160 | nM | EC50 | J Med Chem (2010) 53: 4488-4501 [PMID:20446735] |
| GtoPdb | - | - | 7.13 | pEC50 | 74 | nM | EC50 | Mol Pharmacol (2009) 76: 1341-8 [PMID:19759354] |
| P2Y14 receptor in Rat [GtoPdb: 330] [UniProtKB: O35881] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | J Pharmacol Exp Ther (2008) 325: 588-94 [PMID:18252808] |
| P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
| ChEMBL | Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2) | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| ChEMBL | Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay | F | 4.78 | pEC50 | 16500 | nM | EC50 | J Med Chem (2011) 54: 2878-2890 [PMID:21417463] |
| ChEMBL | Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y2 receptor | F | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2001) 11: 157-160 [PMID:11206448] |
| P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582] | ||||||||
| ChEMBL | Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay | F | 4.85 | pEC50 | 14000 | nM | EC50 | J Med Chem (2011) 54: 2878-2890 [PMID:21417463] |
| P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077] | ||||||||
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production | F | 6.28 | pEC50 | 530 | nM | EC50 | J Med Chem (2010) 53: 471-480 [PMID:19902968] |
| GtoPdb | - | - | 6.5 | pEC50 | - | - | - | Biochem Biophys Res Commun (1996) 222: 303-8 [PMID:8670200] |
| ChEMBL | The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6) | F | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay | F | 6.52 | pEC50 | 300 | nM | EC50 | Bioorg Med Chem (2008) 16: 6319-6332 [PMID:18514530] |
| ChEMBL | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay | F | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2010) 53: 4488-4501 [PMID:20446735] |
| ChEMBL | Agonist activity at human GFP-tagged P2Y6 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based fluorescence spectrophotometry | F | 6.82 | pEC50 | 150 | nM | EC50 | Bioorg Med Chem (2012) 20: 5483-5495 [PMID:22901672] |
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assay | F | 6.85 | pEC50 | 140 | nM | EC50 | J Med Chem (2010) 53: 1673-1685 [PMID:20095577] |
| ChEMBL | Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptor | F | 7 | pEC50 | 100 | nM | EC50 | Bioorg Med Chem Lett (2001) 11: 157-160 [PMID:11206448] |
| ChEMBL | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor | B | 7.07 | pEC50 | 86 | nM | EC50 | J Med Chem (2005) 48: 8108-8111 [PMID:16366591] |
| ChEMBL | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay | F | 7.32 | pEC50 | 48 | nM | EC50 | J Med Chem (2011) 54: 2878-2890 [PMID:21417463] |
| ChEMBL | Agonist activity at human P2Y6 receptor | F | 7.33 | pEC50 | 47 | nM | EC50 | Bioorg Med Chem (2012) 20: 5483-5495 [PMID:22901672] |
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA | F | 7.38 | pEC50 | 42 | nM | EC50 | J Med Chem (2006) 49: 7076-7087 [PMID:17125260] |
| ChEMBL | Agonist activity at P2Y6 receptor expressed in human 1321N1 cells assessed as inositol phosphate accumulation | F | 7.82 | pEC50 | 15 | nM | EC50 | Bioorg Med Chem (2012) 20: 5483-5495 [PMID:22901672] |
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 6 (hP2Y6) stably expressed in 131N1 astrocytoma cell | F | 7.82 | pEC50 | 15 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| ChEMBL | Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production | F | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2006) 49: 5532-5543 [PMID:16942026] |
| P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3543] [GtoPdb: 326] [UniProtKB: Q63371] | ||||||||
| ChEMBL | Agonist activity at rat P2Y6 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis | F | 6.7 | pEC50 | 200 | nM | EC50 | Eur J Med Chem (2009) 44: 1525-1536 [PMID:18760862] |
| ChEMBL | Agonist activity at rat P2Y purinoceptor 6 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetry | F | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (2012) 55: 437-448 [PMID:22107038] |
| UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5955] [UniProtKB: O15294] | ||||||||
| ChEMBL | Inhibition of human OGT | B | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1199-1201 [PMID:21273069] |
| GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304] | ||||||||
| GtoPdb | [35S]GTPγS binding to 1321N1 cell membranes expressing hGPR17. | - | 8.8 | pEC50 | 1.6 | nM | EC50 |
Br J Pharmacol (2010) 159: 1092-105 [PMID:20148890]; EMBO J (2006) 25: 4615-27 [PMID:16990797] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
