LTD4 [Ligand Id: 3353] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1521056
  • GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304]
  • GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
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  • CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
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  • CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304]
GtoPdb [35S]GTPγS binding to COS-7 cell membranes expressing hGPR17. - 8.36 pEC50 4.4 nM EC50 EMBO J (2006) 25: 4615-27 [PMID:16990797]
GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
GtoPdb - - 9.2 pEC50 0.63 nM EC50 PLoS ONE (2008) 3: e3579 [PMID:18974869]
CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
GtoPdb - - 8.05 pIC50 9 nM IC50 Mol Pharmacol (1999) 56: 657-63 [PMID:10462554]
GtoPdb - - 8.47 pEC50 3.4 nM EC50 Prostaglandins Other Lipid Mediat (2003) 71: 235-51 [PMID:14518564]
GtoPdb - - 8.52 pEC50 3 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245]
GtoPdb - - 9.22 pEC50 0.6 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245];
Mol Pharmacol (1999) 56: 657-63 [PMID:10462554];
Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337];
Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801];
FASEB J (2011) 25: 3519-28 [PMID:21753081];
Pharmacogenet Genomics (2007) 17: 539-49 [PMID:17558309]
GtoPdb - - 9.4 pEC50 0.4 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245]
CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
GtoPdb - - 8.1 pKi - - - Mol Pharmacol (1998) 53: 750-8 [PMID:9547367]
GtoPdb - - 7.23 pIC50 59 nM IC50 Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]
GtoPdb - - 8.15 pIC50 7 nM IC50 Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
GtoPdb - - 6.98 pEC50 104 nM EC50 J Biol Chem (2000) 275: 30531-6 [PMID:10851239];
Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
GtoPdb - - 7.44 pEC50 36 nM EC50 FASEB J (2011) 25: 3519-28 [PMID:21753081]
GtoPdb - - 7.46 pEC50 35 nM EC50 Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
GtoPdb - - 8.6 pEC50 2.5 nM EC50 Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337];
Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801];
FASEB J (2011) 25: 3519-28 [PMID:21753081]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]