LTD4 [Ligand Id: 3353] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1521056
  • GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304]
  • GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
There should be some charts here, you may need to enable JavaScript!
  • CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
There should be some charts here, you may need to enable JavaScript!
  • CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304]
GtoPdb [35S]GTPγS binding to COS-7 cell membranes expressing hGPR17. - 8.36 pEC50 4.4 nM EC50 EMBO J (2006) 25: 4615-27 [PMID:16990797]
GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
GtoPdb - - 9.2 pEC50 0.63 nM EC50 PLoS ONE (2008) 3: e3579 [PMID:18974869]
CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
GtoPdb - - 8.05 pIC50 9 nM IC50 Mol Pharmacol (1999) 56: 657-63 [PMID:10462554]
GtoPdb - - 8.47 pEC50 3.4 nM EC50 Prostaglandins Other Lipid Mediat (2003) 71: 235-51 [PMID:14518564]
GtoPdb - - 8.52 pEC50 3 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245]
GtoPdb - - 9.22 pEC50 0.6 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245];
Mol Pharmacol (1999) 56: 657-63 [PMID:10462554];
Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337];
Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801];
FASEB J (2011) 25: 3519-28 [PMID:21753081];
Pharmacogenet Genomics (2007) 17: 539-49 [PMID:17558309]
GtoPdb - - 9.4 pEC50 0.4 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245]
CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
GtoPdb - - 8.1 pKi - - - Mol Pharmacol (1998) 53: 750-8 [PMID:9547367]
GtoPdb - - 7.23 pIC50 59 nM IC50 Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]
GtoPdb - - 8.15 pIC50 7 nM IC50 Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
GtoPdb - - 6.98 pEC50 104 nM EC50 J Biol Chem (2000) 275: 30531-6 [PMID:10851239];
Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
GtoPdb - - 7.44 pEC50 36 nM EC50 FASEB J (2011) 25: 3519-28 [PMID:21753081]
GtoPdb - - 7.46 pEC50 35 nM EC50 Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
GtoPdb - - 8.6 pEC50 2.5 nM EC50 Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337];
Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801];
FASEB J (2011) 25: 3519-28 [PMID:21753081]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]