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ChEMBL ligand: CHEMBL1521056 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304] | ||||||||
GtoPdb | [35S]GTPγS binding to COS-7 cell membranes expressing hGPR17. | - | 8.36 | pEC50 | 4.4 | nM | EC50 | EMBO J (2006) 25: 4615-27 [PMID:16990797] |
GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65] | ||||||||
GtoPdb | - | - | 9.2 | pEC50 | 0.63 | nM | EC50 | PLoS ONE (2008) 3: e3579 [PMID:18974869] |
CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271] | ||||||||
GtoPdb | - | - | 8.05 | pIC50 | 9 | nM | IC50 | Mol Pharmacol (1999) 56: 657-63 [PMID:10462554] |
GtoPdb | - | - | 8.47 | pEC50 | 3.4 | nM | EC50 | Prostaglandins Other Lipid Mediat (2003) 71: 235-51 [PMID:14518564] |
GtoPdb | - | - | 8.52 | pEC50 | 3 | nM | EC50 | Nature (1999) 399: 789-93 [PMID:10391245] |
GtoPdb | - | - | 9.22 | pEC50 | 0.6 | nM | EC50 |
Nature (1999) 399: 789-93 [PMID:10391245]; Mol Pharmacol (1999) 56: 657-63 [PMID:10462554]; Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]; FASEB J (2011) 25: 3519-28 [PMID:21753081]; Pharmacogenet Genomics (2007) 17: 539-49 [PMID:17558309] |
GtoPdb | - | - | 9.4 | pEC50 | 0.4 | nM | EC50 | Nature (1999) 399: 789-93 [PMID:10391245] |
CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75] | ||||||||
GtoPdb | - | - | 8.1 | pKi | - | - | - | Mol Pharmacol (1998) 53: 750-8 [PMID:9547367] |
GtoPdb | - | - | 7.23 | pIC50 | 59 | nM | IC50 | Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337] |
GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
GtoPdb | - | - | 6.98 | pEC50 | 104 | nM | EC50 |
J Biol Chem (2000) 275: 30531-6 [PMID:10851239]; Mol Pharmacol (2011) 79: 270-8 [PMID:21078884] |
GtoPdb | - | - | 7.44 | pEC50 | 36 | nM | EC50 | FASEB J (2011) 25: 3519-28 [PMID:21753081] |
GtoPdb | - | - | 7.46 | pEC50 | 35 | nM | EC50 | Mol Pharmacol (2011) 79: 270-8 [PMID:21078884] |
GtoPdb | - | - | 8.6 | pEC50 | 2.5 | nM | EC50 |
Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]; FASEB J (2011) 25: 3519-28 [PMID:21753081] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]