Ro19-4603 [Ligand Id: 4297] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL269366 (Ro-194603)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit/GABA-A receptor; anion channel in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907607] [GtoPdb: 419, 410, 416, 414, 408, 406, 413, 405, 407, 415, 409, 404, 412, 411, 417] [UniProtKB: O09028, P15431, P18506, P18508, P19969, P20236, P23574, P23576, P28471, P28473, P30191, P62813, P63079, P63138, Q91ZM7, Q9ES14]
ChEMBL Binding affinity against Diazepam insensitive (DI) Gamma-aminobutyric acid A receptor B 8.59 pKi 2.6 nM Ki J Med Chem (1995) 38: 1679-1688 [PMID:7752192]
ChEMBL Binding affinity for Diazepam-Insensitive fraction of GABA-A benzodiazepine receptors B 8.59 pKi 2.6 nM Ki J Med Chem (1993) 36: 1001-1006 [PMID:8386769]
ChEMBL Binding affinity for Diazepam insensitive (DI) isoform of the benzodiazepine (Bz) binding site on GABAA receptors B 8.59 pKi 2.6 nM Ki J Med Chem (1993) 36: 1820-1830 [PMID:8390574]
ChEMBL Binding affinity against Diazepam sensitive (DS) Gamma-aminobutyric acid A receptor in rat cerebellum. B 9.7 pKi 0.2 nM Ki J Med Chem (1995) 38: 1679-1688 [PMID:7752192]
ChEMBL Binding affinity for Diazepam-Sensitive fraction of GABA-A benzodiazepine receptors B 9.7 pKi 0.2 nM Ki J Med Chem (1993) 36: 1001-1006 [PMID:8386769]
ChEMBL Binding affinity for Diazepam sensitive (DS) isoform of the benzodiazepine (Bz) binding site on GABAA receptors B 9.7 pKi 0.2 nM Ki J Med Chem (1993) 36: 1820-1830 [PMID:8390574]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]