Ro19-4603 [Ligand Id: 4297] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL269366 (Ro-194603)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit/GABA-A receptor; anion channel in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907607] [GtoPdb: 419410416414408406413405407415409404412411417] [UniProtKB: O09028P15431P18506P18508P19969P20236P23574P23576P28471P28473P30191P62813P63079P63138Q91ZM7Q9ES14]
ChEMBL Binding affinity against Diazepam insensitive (DI) Gamma-aminobutyric acid A receptor B 8.59 pKi 2.6 nM Ki J. Med. Chem. (1995) 38: 1679-1688 [PMID:7752192]
ChEMBL Binding affinity for Diazepam-Insensitive fraction of GABA-A benzodiazepine receptors B 8.59 pKi 2.6 nM Ki J. Med. Chem. (1993) 36: 1001-1006 [PMID:8386769]
ChEMBL Binding affinity for Diazepam insensitive (DI) isoform of the benzodiazepine (Bz) binding site on GABAA receptors B 8.59 pKi 2.6 nM Ki J. Med. Chem. (1993) 36: 1820-1830 [PMID:8390574]
ChEMBL Binding affinity against Diazepam sensitive (DS) Gamma-aminobutyric acid A receptor in rat cerebellum. B 9.7 pKi 0.2 nM Ki J. Med. Chem. (1995) 38: 1679-1688 [PMID:7752192]
ChEMBL Binding affinity for Diazepam-Sensitive fraction of GABA-A benzodiazepine receptors B 9.7 pKi 0.2 nM Ki J. Med. Chem. (1993) 36: 1001-1006 [PMID:8386769]
ChEMBL Binding affinity for Diazepam sensitive (DS) isoform of the benzodiazepine (Bz) binding site on GABAA receptors B 9.7 pKi 0.2 nM Ki J. Med. Chem. (1993) 36: 1820-1830 [PMID:8390574]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]