MGS0028 [Ligand Id: 1395] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL121053 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416] | ||||||||
| ChEMBL | Agonist activity at mGLUR2 expressed in CHO cells | F | 9.24 | pEC50 | 0.57 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 1958-1962 [PMID:22318160] |
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2851] [GtoPdb: 290] [UniProtKB: P31421] | ||||||||
| ChEMBL | Tested for binding affinity against Metabotropic glutamate receptor 2 in CHO cells using [3H]-7 as radioligand | B | 8.48 | pKi | 3.3 | nM | Ki | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| GtoPdb | - | - | 9.2 | pKi | - | - | - | J Med Chem (2000) 43: 4893-909 [PMID:11123999] |
| ChEMBL | Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated in presence of 30 uM glutamic acid | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation | F | 7.02 | pEC50 | 94.7 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation | F | 8.9 | pEC50 | 1.26 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation | F | 9.24 | pEC50 | 0.57 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| mGlu3 receptor/Metabotropic glutamate receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2888] [GtoPdb: 291] [UniProtKB: Q14832] | ||||||||
| ChEMBL | Agonist activity at mGLUR3 expressed in CHO cells | F | 8.68 | pEC50 | 2.07 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 1958-1962 [PMID:22318160] |
| mGlu3 receptor/Metabotropic glutamate receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3067] [GtoPdb: 291] [UniProtKB: P31422] | ||||||||
| ChEMBL | Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligand | B | 8.44 | pKi | 3.62 | nM | Ki | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Antagonist activity against Metabotropic glutamate receptor 3 expressed in CHO cells was evaluated in presence of 30 uM glutamic acid | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Agonist potency against cloned Metabotropic glutamate receptor 3 | F | 8.68 | pEC50 | 2.07 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
