ChEMBL ligand: CHEMBL253144 (11-deoxycortisol, 11-deoxycortisone, 11-deoxyhydrocortisone, 17,21-dihydroxyprogesterone, 17.alpha.-hydroxycortexone, 17-hydroxy-11-deoxycorticosterone, Cortexolone, Cortifen, Cortisol, 11-deoxy-, Cortodoxona, Cortodoxone, NSC-18317, Reichstein's substance s, Skf-3050, SK&F 3050, SK&F-3050, Substance s)
Corticosteroid-binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Sex hormone-binding globulin in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Corticosteroid-binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	In silico binding affinity to human corticosteriod binding globulin	B	6.88	pKd	6.88	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	7.88	pKi	13.18	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
Sex hormone-binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Binding affinity towards human testosterone binding globulin.	B	6.2	pKd	6.2	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	7.44	pKd	36.31	nM	Kd	J Med Chem (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]