alunacedase alfa   Click here for help

GtoPdb Ligand ID: 11320

Synonyms: APN01 | GSK-2586881 | GSK2586881 | rhsACE2
Compound class: Peptide
Comment: Alunacedase alfa (APN01; Aperion Biologics) is a recombinant version of human ACE2 that is intended to act as a decoy (soluble trap) for the SARS-CoV-2 spike protein [1,4-5], than can neutralise the virus [4]. Recombinant ACE2 was originally proposed as a mechanism to combat acute respiratory distress syndrome (ARDS) caused by the SARS-CoV virus [2], which like SARS-CoV-2 uses ACE2 to infect host cells. Structurally APN01 is a glycosylated dimer of peptide chains that form the extracellular domain of the enzyme. It is produced in Chinese hamster ovary (CHO) cells, and it contains several intra-subunit disulphide bridges.
Classification Click here for help
Compound class Peptide
International Nonproprietary Names Click here for help
INN number INN
11856 alunacedase alfa
Synonyms Click here for help
APN01 | GSK-2586881 | GSK2586881 | rhsACE2
Database Links Click here for help
GtoPdb PubChem SID 434321755
Search PubMed clinical trials alunacedase alfa
Search PubMed titles alunacedase alfa
Search PubMed titles/abstracts alunacedase alfa