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Synonyms: APN01 | GSK-2586881 | GSK2586881 | rhsACE2
Compound class:
Peptide or derivative
Comment: Alunacedase alfa (APN01; Aperion Biologics) is a recombinant version of human ACE2 that is intended to act as a decoy (soluble trap) for the SARS-CoV-2 spike protein [1,4-5], than can neutralise the virus [4]. Recombinant ACE2 was originally proposed as a mechanism to combat acute respiratory distress syndrome (ARDS) caused by the SARS-CoV virus [2], which like SARS-CoV-2 uses ACE2 to infect host cells. Structurally APN01 is a glycosylated dimer of peptide chains that form the extracellular domain of the enzyme. It is produced in Chinese hamster ovary (CHO) cells, and it contains several intra-subunit disulphide bridges.
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Peptide Sequence  |
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QSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQL QALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLR PLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYIS PIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPG NVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKH LKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY CDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAK NMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLK VKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRL700NDNSLEFLGIQPTLGPP NQPPVS |
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