VU0364770 [Ligand Id: 6234] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL556667 (N-(3-Chlorophenyl)Picolinamide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833] | ||||||||
| ChEMBL | Positive allosteric modulator activity at human mGlu4 receptor | B | 5.92 | pEC50 | 1196 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 3956-3960 [PMID:26231155] |
| ChEMBL | Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilization | F | 5.96 | pEC50 | 1100 | nM | EC50 | J Med Chem (2009) 52: 4115-4118 [PMID:19469556] |
| ChEMBL | Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux preincubated for 2.5 mins followed by glutamate addition by Fluo-4-AM dye based fluorescence assay | F | 5.96 | pEC50 | 1100 | nM | EC50 | Bioorg Med Chem Lett (2018) 28: 2641-2646 [PMID:29958762] |
| GtoPdb | - | - | 6 | pEC50 | 1100 | nM | EC50 | J Pharmacol Exp Ther (2012) 340: 404-21 [PMID:22088953] |
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423] | ||||||||
| ChEMBL | Positive allosteric modulator activity at rat mGlu4 receptor | B | 6.48 | pEC50 | 330 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 3956-3960 [PMID:26231155] |
| GtoPdb | - | - | 6.5 | pEC50 | 290 | nM | EC50 | J Pharmacol Exp Ther (2012) 340: 404-21 [PMID:22088953] |
| ChEMBL | Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium flux | B | 6.54 | pEC50 | 290 | nM | EC50 | J Med Chem (2009) 52: 4115-4118 [PMID:19469556] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
