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ChEMBL ligand: CHEMBL417799 (Pseudochelerythrine, Sangrovit, Sanguinarin, Sanguinarine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 5.91 | pIC50 | 1220 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
Bcl2-antagonist of cell death (BAD) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3817] [UniProtKB: Q92934] | ||||||||
ChEMBL | Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assay | B | 4.72 | pIC50 | 19000 | nM | IC50 | J. Med. Chem. (2008) 51: 6699-6710 [PMID:18925736] |
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 5.15 | pIC50 | 7080 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
Nuclear factor NF-kappa-B complex in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094258] [UniProtKB: P19838, Q00653, Q04206] | ||||||||
ChEMBL | Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg. Med. Chem. (2014) 22: 3008-3015 [PMID:24775915] |
regulator of G-protein signaling 17/Regulator of G-protein signaling 17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295974] [GtoPdb: 2801] [UniProtKB: Q9UGC6] | ||||||||
ChEMBL | Binding affinity to RGS17 (unknown origin) by ITC method | B | 6 | pKd | 1000 | nM | Kd | J Nat Prod (2017) 80: 1992-2000 [PMID:28621943] |
ChEMBL | Inhibition of RGS17 (unknown origin) C117A mutant interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2017) 80: 1992-2000 [PMID:28621943] |
ChEMBL | Inhibition of wild type GST-tagged RGS17 (unknown origin) interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assay | B | 4.14 | pIC50 | 72800 | nM | IC50 | J Nat Prod (2017) 80: 1992-2000 [PMID:28621943] |
GtoPdb | - | - | 4.14 | pIC50 | 72800 | nM | IC50 | J Nat Prod (2017) 80: 1992-2000 [PMID:28621943] |
ChEMBL | Inhibition of RGS17 (unknown origin) GAP activity in presence of GTP by malachite green dye based assay | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Nat Prod (2017) 80: 1992-2000 [PMID:28621943] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]