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ChEMBL ligand: CHEMBL225519 (PHA-767491) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Inhibition of Alk | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
ChEMBL | Inhibition of PKAalpha | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] | ||||||||
ChEMBL | Inhibition of human Cdc7 | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2008) 51: 487-501 [PMID:18201066] |
ChEMBL | Inhibition of human Cdc7 assessed as inhibition of rate of phosphorylation of Mcm2 protein | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ChEMBL | Inhibition of cdc7 | B | 8 | pIC50 | 10 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ChEMBL | Inhibition of Cdc7 | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
ChEMBL | Inhibition of cdk1 | B | 6.6 | pIC50 | 250 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ChEMBL | Inhibition of CDK2 | B | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of cdk2 | B | 6.62 | pIC50 | 240 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
ChEMBL | Inhibition of cdk5 | B | 6.34 | pIC50 | 460 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
ChEMBL | Inhibition of Cdk7 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
ChEMBL | Inhibition of CDK9 | B | 7.47 | pIC50 | 34 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ChEMBL | Inhibition of cdk9 | B | 7.47 | pIC50 | 34 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Inhibition of FGFR1 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 6.66 | pIC50 | 220 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of c-Met | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK2 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
ChEMBL | Inhibition of IKK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of IR | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of Mk2 | B | 6.33 | pIC50 | 470 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ChEMBL | Inhibition of MK2 | B | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
GtoPdb | - | - | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2007) 50: 2647-54 [PMID:17480064] |
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644] | ||||||||
ChEMBL | Inhibition of MK3 | B | 4.24 | pIC50 | 57700 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
ChEMBL | Inhibition of MK5 | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
ChEMBL | Inhibition of MNK1 | B | 5.57 | pIC50 | 2670 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
ChEMBL | Inhibition of MNK1 | B | 5.57 | pIC50 | 2670 | nM | IC50 | J Med Chem (2010) 53: 6618-6628 [PMID:20722422] |
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
ChEMBL | Inhibition of P38beta | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9] | ||||||||
ChEMBL | Inhibition of MNK2 | B | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2010) 53: 6618-6628 [PMID:20722422] |
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
ChEMBL | Inhibition of TRKA | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
ChEMBL | Inhibition of PKCbeta | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
ChEMBL | Inhibition of PDK1 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676] | ||||||||
GtoPdb | - | - | 5.52 | pIC50 | 3010 | nM | IC50 | J Med Chem (2007) 50: 2647-54 [PMID:17480064] |
ChEMBL | Inhibition of MSK2 | B | 5.52 | pIC50 | 3010 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582] | ||||||||
ChEMBL | Inhibition of MSK1 | B | 5.63 | pIC50 | 2340 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
STE20 like kinase/Serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2] | ||||||||
ChEMBL | Inhibition of STLK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of AKT1 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of Aurora-A | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Inhibition of Aurora-B | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Inhibition of chk1 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
ChEMBL | Inhibition of chk2 | B | 5.96 | pIC50 | 1100 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98] | ||||||||
ChEMBL | Inhibition of Nek6 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84] | ||||||||
ChEMBL | Inhibition of NIM1 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
ChEMBL | Inhibition of PAK4 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
ChEMBL | Inhibition of plk1 | B | 6.01 | pIC50 | 980 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8] | ||||||||
ChEMBL | Inhibition of TAO3 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Inhibition of c-Kit | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of c-Abl | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of LCK | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
ChEMBL | Inhibition of Ret | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
ChEMBL | Inhibition of ZAP70 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of VEGFR2 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
ChEMBL | Inhibition of VEGFR3 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]