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ChEMBL ligand: CHEMBL225519 (PHA-767491) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Inhibition of Alk | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
ChEMBL | Inhibition of PKAalpha | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] | ||||||||
ChEMBL | Inhibition of human Cdc7 | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2008) 51: 487-501 [PMID:18201066] |
ChEMBL | Inhibition of human Cdc7 assessed as inhibition of rate of phosphorylation of Mcm2 protein | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ChEMBL | Inhibition of cdc7 | B | 8 | pIC50 | 10 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ChEMBL | Inhibition of Cdc7 | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2010) 53: 7296-7315 [PMID:20873740] |
ChEMBL | Inhibition of Cdc7 (unknown origin) | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2022) 65: 893-921 [PMID:33539089] |
ChEMBL | Inhibition of CDC7 (unknown origin) | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2021) 64: 1283-1345 [PMID:33481605] |
ChEMBL | Inhibition of human cdc7 incubation of 30 mins in presence of ATP | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2021) 64: 2382-2418 [PMID:33650861] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
ChEMBL | Inhibition of cdk1 | B | 6.6 | pIC50 | 250 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ChEMBL | Inhibition of CDK2 | B | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of cdk2 | B | 6.62 | pIC50 | 240 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
ChEMBL | Inhibition of cdk5 | B | 6.34 | pIC50 | 460 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
ChEMBL | Inhibition of Cdk7 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
ChEMBL | Inhibition of CDK9 | B | 7.47 | pIC50 | 34 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ChEMBL | Inhibition of cdk9 | B | 7.47 | pIC50 | 34 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ChEMBL | Inhibition of CDK9 (unknown origin) | B | 7.47 | pIC50 | 34 | nM | IC50 | J Med Chem (2022) 65: 893-921 [PMID:33539089] |
ChEMBL | Inhibition of human CDK9 incubation of 30 mins in presence of ATP | B | 7.47 | pIC50 | 34 | nM | IC50 | J Med Chem (2021) 64: 2382-2418 [PMID:33650861] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Inhibition of FGFR1 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 6.66 | pIC50 | 220 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of c-Met | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK2 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
ChEMBL | Inhibition of IKK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of IR | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of Mk2 | B | 6.33 | pIC50 | 470 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
ChEMBL | Inhibition of MK2 | B | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
GtoPdb | - | - | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2007) 50: 2647-54 [PMID:17480064] |
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644] | ||||||||
ChEMBL | Inhibition of MK3 | B | 4.24 | pIC50 | 57700 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
ChEMBL | Inhibition of MK5 | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
ChEMBL | Inhibition of MNK1 | B | 5.57 | pIC50 | 2670 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
ChEMBL | Inhibition of MNK1 | B | 5.57 | pIC50 | 2670 | nM | IC50 | J Med Chem (2010) 53: 6618-6628 [PMID:20722422] |
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
ChEMBL | Inhibition of P38beta | B | 5 | pIC50 | >10000 | nM | IC50 | Nat Chem Biol (2008) 4: 357-365 [PMID:18469809] |
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9] | ||||||||