5-oxo-12-HETE [Ligand Id: 6171] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3115778
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OXE receptor/Oxoeicosanoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628461] [GtoPdb: 271] [UniProtKB: Q8TDS5]
GtoPdb - - 6.3 pIC50 500 nM IC50 Blood (1999) 93: 1086-96 [PMID:9920859]
ChEMBL Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis F 6.3 pIC50 500 nM IC50 J. Med. Chem. (2014) 57: 364-377 [PMID:24351031]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]