compound 5a [PMID: 20690647] [Ligand Id: 8615] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1240872 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Calpain 1 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4062] [UniProtKB: P35750] | ||||||||
| ChEMBL | Inhibition of porcine erythrocyte calpain 1 | B | 7.26 | pKi | 55 | nM | Ki | J Med Chem (2010) 53: 6326-6336 [PMID:20690647] |
| Calpain 2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4143] [UniProtKB: P43367] | ||||||||
| ChEMBL | Inhibition of porcine kidney calpain 2 | B | 7.17 | pKi | 68 | nM | Ki | J Med Chem (2010) 53: 6326-6336 [PMID:20690647] |
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of human liver cathepsin B | B | 5.76 | pKi | 1750 | nM | Ki | J Med Chem (2010) 53: 6326-6336 [PMID:20690647] |
| calpain 2 in Pig [GtoPdb: 2337] | ||||||||
| GtoPdb | - | - | 7.17 | pKi | 68 | nM | Ki | J Med Chem (2010) 53: 6326-36 [PMID:20690647] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
