ChEMBL ligand: CHEMBL325372 (E-218, E218, FEMA NO. 2710, INS-218, INS NO.218, Killitol, Methylis hydroxybenzoas, Methyl paraben, Methylparaben, Methyl paraben (e218), Methylparaben e218, Methyl parahydroxybenzoate, Methyl p-hydroxybenzoate, Methyl p-oxybenzoate, Moldex, NSC-3827, NSC-406127, P-hydroxybenzoic methyl ester, Preserval m, Tegosept m)
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] There should be some charts here, you may need to enable JavaScript!
xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] There should be some charts here, you may need to enable JavaScript!
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	5.59	pKi	2600	nM	Ki	Bioorg Med Chem (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	5.47	pKi	3400	nM	Ki	Bioorg Med Chem (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	5.26	pKi	5500	nM	Ki	Bioorg Med Chem (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL	Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.11	pKi	780	nM	Ki	Bioorg Med Chem (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.09	pKi	820	nM	Ki	Bioorg Med Chem (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL	Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	5.39	pKi	4100	nM	Ki	Bioorg Med Chem (2013) 21: 1564-1569 [PMID:22668600]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL	Inhibition of xanthine oxidase-mediated formation of uric acid by spectrophotometry	B	4.3	pIC50	>50000	nM	IC50	J Nat Prod (2002) 65: 1526-1529 [PMID:12444671]
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb	Patch clamp	-	2.4	pEC50	-	-	-	Br J Pharmacol (2007) 151: 153-60 [PMID:17351650]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]