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ChEMBL ligand: CHEMBL468927 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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coactivator associated arginine methyltransferase 1/Histone-arginine methyltransferase CARM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5406] [GtoPdb: 1255] [UniProtKB: Q86X55] | ||||||||
ChEMBL | Inhibition of CARM1 assessed as blockade of histone H3 methylation | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2924-2927 [PMID:19419866] |
GtoPdb | - | - | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2924-7 [PMID:19419866] |
ChEMBL | Inhibition of human CARM1 assessed as inhibition of histone3 methylation | B | 10.4 | pIC50 | 0.04 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5063-5066 [PMID:19632837] |
Pregnane X receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3401] [GtoPdb: 606] [UniProtKB: O75469] | ||||||||
ChEMBL | Inhibition of human PXR | B | 4.6 | pEC50 | >25000 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 2924-2927 [PMID:19419866] |
protein arginine methyltransferase 1 /Protein-arginine N-methyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5524] [GtoPdb: 1252] [UniProtKB: Q99873] | ||||||||
ChEMBL | Inhibition of PRMT1 by methylation assay | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2924-2927 [PMID:19419866] |
protein arginine methyltransferase 3/Protein arginine N-methyltransferase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5891] [GtoPdb: 1254] [UniProtKB: O60678] | ||||||||
ChEMBL | Inhibition of PRMT3 by methylation assay | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2924-2927 [PMID:19419866] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]