yzm18 [Ligand Id: 8853] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL570714
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
taspase 1/Threonine aspartase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6153] [GtoPdb: 2419] [UniProtKB: Q9H6P5]
GtoPdb - - 4.53 pIC50 29400 nM IC50 Bioorg Med Chem Lett (2009) 19: 5086-90 [PMID:19631530]
ChEMBL Inhibition of recombinant Taspase 1 assessed as accumulation of emitted fluorescence by FRET assay B 4.53 pIC50 29400 nM IC50 Bioorg Med Chem Lett (2009) 19: 5086-5090 [PMID:19631530]
ChEMBL Inhibition of recombinant Taspase1 (unknown origin) using [35S]-methionine labeled human MLL1 (2400-2900 residues) as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by SDS-PAGE based autoradiography B 4.53 pIC50 29400 nM IC50 US-8501811-B2. TASPASE1 inhibitors and their uses (null)

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]