yzm18 [Ligand Id: 8853] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL570714
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
taspase 1/Threonine aspartase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6153] [GtoPdb: 2419] [UniProtKB: Q9H6P5]
GtoPdb - - 4.53 pIC50 29400 nM IC50 Bioorg Med Chem Lett (2009) 19: 5086-90 [PMID:19631530]
ChEMBL Inhibition of recombinant Taspase 1 assessed as accumulation of emitted fluorescence by FRET assay B 4.53 pIC50 29400 nM IC50 Bioorg Med Chem Lett (2009) 19: 5086-5090 [PMID:19631530]
ChEMBL Inhibition of recombinant Taspase1 (unknown origin) using [35S]-methionine labeled human MLL1 (2400-2900 residues) as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by SDS-PAGE based autoradiography B 4.53 pIC50 29400 nM IC50 US-8501811-B2. TASPASE1 inhibitors and their uses (2013)

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]