MK 6892 [Ligand Id: 5788] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1086657 (MK-6892)
  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Mouse [ChEMBL: CHEMBL4420] [GtoPdb: 312] [UniProtKB: Q9EP66]
  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Rat [ChEMBL: CHEMBL4731] [GtoPdb: 312] [UniProtKB: Q80Z39]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
ChEMBL Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin B 6.23 pKi 595 nM Ki J Med Chem (2010) 53: 2666-2670 [PMID:20184326]
ChEMBL Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry B 8.4 pKi 4 nM Ki J Med Chem (2010) 53: 2666-2670 [PMID:20184326]
GtoPdb - - 8.4 pKi 4 nM Ki J Med Chem (2010) 53: 2666-70 [PMID:20184326]
ChEMBL Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay F 7.8 pEC50 16 nM EC50 J Med Chem (2010) 53: 2666-2670 [PMID:20184326]
GtoPdb - - 7.8 pEC50 16 nM EC50 J Med Chem (2010) 53: 2666-70 [PMID:20184326]
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4420] [GtoPdb: 312] [UniProtKB: Q9EP66]
ChEMBL Agonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assay F 6.62 pEC50 240 nM EC50 J Med Chem (2010) 53: 2666-2670 [PMID:20184326]
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4731] [GtoPdb: 312] [UniProtKB: Q80Z39]
ChEMBL Agonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assay F 5.34 pEC50 4600 nM EC50 J Med Chem (2010) 53: 2666-2670 [PMID:20184326]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]