MK 6892 [Ligand Id: 5788] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1086657 (MK-6892) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
| ChEMBL | Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin | B | 6.23 | pKi | 595 | nM | Ki | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
| ChEMBL | Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
| GtoPdb | - | - | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2010) 53: 2666-70 [PMID:20184326] |
| ChEMBL | Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay | F | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
| GtoPdb | - | - | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2010) 53: 2666-70 [PMID:20184326] |
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4420] [GtoPdb: 312] [UniProtKB: Q9EP66] | ||||||||
| ChEMBL | Agonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assay | F | 6.62 | pEC50 | 240 | nM | EC50 | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4731] [GtoPdb: 312] [UniProtKB: Q80Z39] | ||||||||
| ChEMBL | Agonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assay | F | 5.34 | pEC50 | 4600 | nM | EC50 | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
