voxelotor [Ligand Id: 10559] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4101807 (Gbt440, GBT-440, GBT440, GTX-011, Oxbryta, Voxelotor) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| CYP2C8 in Human [GtoPdb: 1325] [UniProtKB: P10632] | ||||||||
| GtoPdb | Measuring inhibition of CYP2C8 activity using paclitaxel as substrate. | - | 5.1 | pIC50 | 7900 | nM | IC50 | ACS Med Chem Lett (2017) 8: 321-326 [PMID:28337324] |
| CYP2C9 in Human [GtoPdb: 1326] [UniProtKB: P11712] | ||||||||
| GtoPdb | Measuring inhibition of CYP2C9 activity using tolbutamide as substrate. | - | 5.07 | pIC50 | 8500 | nM | IC50 | ACS Med Chem Lett (2017) 8: 321-326 [PMID:28337324] |
| CYP3A4 in Human [GtoPdb: 1337] [UniProtKB: P08684] | ||||||||
| GtoPdb | Measuring inhibition of CYP3A4 activity using testosterone as substrate. | - | 4.9 | pIC50 | 12500 | nM | IC50 | ACS Med Chem Lett (2017) 8: 321-326 [PMID:28337324] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
