4α-PDH [Ligand Id: 4105] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL490470 (4Alpha-Phorbol 12,13-Dihexanoate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV4/Transient receptor potential cation channel subfamily V member 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6126] [GtoPdb: 510] [UniProtKB: Q9EPK8] | ||||||||
| ChEMBL | Activation of mouse TRPV4 W586A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 5.55 | pEC50 | 2840 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| ChEMBL | Activation of mouse TRPV4 Y556A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 5.55 | pEC50 | 2790 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| ChEMBL | Activation of mouse TRPV4 S557A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 6.44 | pEC50 | 360 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| GtoPdb | - | - | 7.1 | pEC50 | 79.4 | nM | EC50 | J Med Chem (2009) 52: 2933-9 [PMID:19361196] |
| ChEMBL | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 7.15 | pEC50 | 70 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
