compound 2a (+) [PMID: 8709131] [Ligand Id: 3102] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL279261 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Farnesyltransferase, putative in Leishmania major (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5223] [UniProtKB: Q4Q5W4] | ||||||||
| ChEMBL | Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | B | 7.89 | pIC50 | 13 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461] |
| Farnesyltransferase, putative in Trypanosoma cruzi (strain CL Brener) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5220] [UniProtKB: Q4CXF7] | ||||||||
| ChEMBL | Inhibition of Trypanosoma cruzi squalene synthase | B | 7.21 | pKi | 62 | nM | Ki | Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461] |
| lanosterol synthase/Lanosterol synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3262] [GtoPdb: 2434] [UniProtKB: P48450] | ||||||||
| ChEMBL | Inhibition of compound was measured on rat microsomal Oxidosqualene-lanosterol cyclase | B | 7 | pIC50 | >100 | nM | IC50 | J Med Chem (1999) 42: 1306-1311 [PMID:10197973] |
| squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| ChEMBL | In vitro inhibition against rat microsomal squalene synthase (SS) | B | 6.92 | pIC50 | 121 | nM | IC50 | J Med Chem (1996) 39: 2971-2979 [PMID:8709131] |
| ChEMBL | In vitro inhibition against rat microsomal squalene synthase (SS) | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (1996) 39: 2971-2979 [PMID:8709131] |
| ChEMBL | Compound was measured for the inhibition of rat microsomal squalene synthase enzyme | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (1999) 42: 1306-1311 [PMID:10197973] |
| GtoPdb | In vitro inhibition against rat microsomal squalene synthase (SS) | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (1996) 39: 2971-9 [PMID:8709131] |
| ChEMBL | In vitro inhibition against rat microsomal squalene synthase (SS) | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (1996) 39: 2971-2979 [PMID:8709131] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
