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ChEMBL ligand: CHEMBL366266 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
ChEMBL | Inhibitory concentration against recombinant human Protein kinase C alpha | B | 6.48 | pIC50 | 331 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
ChEMBL | Inhibition of PKCalpha | B | 6.48 | pIC50 | 331 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
ChEMBL | Inhibitory concentration against recombinant human Protein kinase C beta 1 | B | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
ChEMBL | Inhibition of PKCbeta2 (unknown origin) | B | 8.3 | pIC50 | 5.01 | nM | IC50 | Med Chem Res (2011) 20: 1188-1199 |
GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-4 [PMID:15380221] |
ChEMBL | Inhibitory concentration against recombinant human Protein kinase C beta 2 | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
ChEMBL | Inhibition of PKCbeta | B | 8.3 | pIC50 | 5 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of PKCbeta2 (unknown origin) | B | 8.3 | pIC50 | 5 | nM | IC50 | Med Chem Res (2011) 20: 1188-1199 |
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
ChEMBL | Inhibitory concentration against recombinant human Protein kinase C epsilon | B | 5.55 | pIC50 | 2807 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
ChEMBL | Inhibition of PKCepsilon | B | 5.55 | pIC50 | 2800 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
ChEMBL | Inhibition of PKCgamma | B | 6 | pIC50 | >1000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
ChEMBL | Inhibition of JAK1 (unknown origin) | B | 6.11 | pIC50 | 770 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 (unknown origin) | B | 5.41 | pIC50 | 3850 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 (unknown origin) | B | 7.77 | pIC50 | 17 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299] |
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
ChEMBL | Inhibition of TYK2 (unknown origin) | B | 5.64 | pIC50 | 2310 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]