PKCbeta inhibitor [Ligand Id: 6025] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL366266 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant human Protein kinase C alpha | B | 6.48 | pIC50 | 331 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
| ChEMBL | Inhibition of PKCalpha | B | 6.48 | pIC50 | 331 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant human Protein kinase C beta 1 | B | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
| ChEMBL | Inhibition of PKCbeta2 (unknown origin) | B | 8.3 | pIC50 | 5.01 | nM | IC50 | Med Chem Res (2011) 20: 1188-1199 |
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-4 [PMID:15380221] |
| ChEMBL | Inhibitory concentration against recombinant human Protein kinase C beta 2 | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
| ChEMBL | Inhibition of PKCbeta | B | 8.3 | pIC50 | 5 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of PKCbeta2 (unknown origin) | B | 8.3 | pIC50 | 5 | nM | IC50 | Med Chem Res (2011) 20: 1188-1199 |
| protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant human Protein kinase C epsilon | B | 5.55 | pIC50 | 2807 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
| ChEMBL | Inhibition of PKCepsilon | B | 5.55 | pIC50 | 2800 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
| ChEMBL | Inhibition of PKCgamma | B | 6 | pIC50 | >1000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| ChEMBL | Inhibition of JAK1 (unknown origin) | B | 6.11 | pIC50 | 770 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299] |
| Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| ChEMBL | Inhibition of JAK2 (unknown origin) | B | 5.41 | pIC50 | 3850 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299] |
| Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| ChEMBL | Inhibition of JAK3 (unknown origin) | B | 7.77 | pIC50 | 17 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299] |
| tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| ChEMBL | Inhibition of TYK2 (unknown origin) | B | 5.64 | pIC50 | 2310 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
