(RS)-PPCC [Ligand Id: 6676] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL222301
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
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  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • D3 receptor/Dopamine D3 receptor in Rat [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
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  • H1 receptor/Histamine H1 receptor in Rat [ChEMBL: CHEMBL4701] [GtoPdb: 262] [UniProtKB: P31390]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
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  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Rat [ChEMBL: CHEMBL2411] [GtoPdb: 373] [UniProtKB: P35563]
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  • Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Rat [ChEMBL: CHEMBL3372] [GtoPdb: 11] [UniProtKB: P31388]
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  • sigma non-opioid intracellular receptor 1 in Human [GtoPdb: 2552] [UniProtKB: Q99720]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL Displacement of [3H]SCH-23390 from rat striatum dopamine D1 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Displacement of [3H]spiperone from rat striatum dopamine D2 receptor B 5.89 pKi 1285 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
ChEMBL Displacement of [3H]7OH-DPAT from rat olfactory tubercle dopamine D3 receptor B 5.31 pKi 4900 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL Displacement of [3H]WIN-35428 from rat striatum DAT B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL Displacement of [3H]CGP-39653 from rat cortex NMDA receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
H1 receptor/Histamine H1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4701] [GtoPdb: 262] [UniProtKB: P31390]
ChEMBL Displacement of [3H]pyrilamine from rat cortex histamine H1 receptor B 5.85 pKi 1422 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL Displacement of [3H]ketanserin from rat cortex 5HT2A receptor B 5.5 pKi 3149 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Displacement of [3H]mesulergine from guinea pig cortex 5HT2C receptor B 5.36 pKi 4357 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2411] [GtoPdb: 373] [UniProtKB: P35563]
ChEMBL Displacement of [3H]LY278584 from rat cortex 5HT3 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL Displacement of [3H]GR-13808 from guinea pig cortex 5HT4 receptor B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3372] [GtoPdb: 11] [UniProtKB: P31388]
ChEMBL Displacement of [3H]5HT from rat cloned 5HT6 receptor expressed in HEK293 cells B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL Displacement of [3H]citalopram from rat cortex SERT B 5 pKi >10000 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492]
ChEMBL Displacement of [3H](+)-pentazocine from guinea pig sigma1 opioid receptor by liquid scintillation counting B 8.74 pKi 1.8 nM Ki J Med Chem (2010) 53: 5881-5885 [PMID:20684615]
ChEMBL Displacement of [3H](+)-pentazocine from guinea pig brain sigma 1 receptor B 8.82 pKi 1.5 nM Ki J Med Chem (2007) 50: 951-961 [PMID:17328523]
sigma non-opioid intracellular receptor 1 in Human [GtoPdb: 2552] [UniProtKB: Q99720]
GtoPdb - - 8.8 pKi - - - J Med Chem (2007) 50: 951-61 [PMID:17328523]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]